Evidence map›Paper›PMID 41572585›Full record

ArticleLupus2026

Serum BAFF levels in pregnant patients with systemic lupus erythematosus.

Catherine A Sims, Amanda M Eudy, Samir Soneji, Kateena Addae-Konadu, Jennifer Gilner, Andra H James, Jerome J Federspiel, Eugene Kovalik, Anika Lucas, Laura Neil and 2 more

Abstract read
In one paragraph

Article in Lupus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Catherine A SimsDepartment of Medicine, Division of Rheumatology, Duke University, Durham, NC, USA.ORCID 0000-0002-2890-4445
Amanda M EudyDepartment of Medicine, Division of Rheumatology, Duke University, Durham, NC, USA.ORCID 0000-0002-3107-5545
Samir SonejiDepartment of Medicine, Division of Rheumatology, Duke University, Durham, NC, USA.
Kateena Addae-KonaduDepartment of Medicine, Division of Rheumatology, Duke University, Durham, NC, USA.
Jennifer GilnerDepartment of Medicine, Division of Rheumatology, Duke University, Durham, NC, USA.
Andra H JamesDepartment of Medicine, Division of Rheumatology, Duke University, Durham, NC, USA.
Jerome J FederspielDepartment of Medicine, Division of Rheumatology, Duke University, Durham, NC, USA.ORCID 0000-0003-0321-6280
Eugene KovalikDepartment of Medicine, Division of Rheumatology, Duke University, Durham, NC, USA.
Anika LucasDepartment of Medicine, Division of Rheumatology, Duke University, Durham, NC, USA.ORCID 0000-0003-1879-3144
Laura NeilDepartment of Medicine, Division of Rheumatology, Duke University, Durham, NC, USA.
Amanda SnydermanDepartment of Medicine, Division of Rheumatology, Duke University, Durham, NC, USA.
Megan Eb ClowseDepartment of Medicine, Division of Rheumatology, Duke University, Durham, NC, USA.

Funding

Duke Women's Reproductive Health Research ScholarsK12HD103083 · NICHD · DUKE UNIVERSITY · PI Cindy Amundsen · 2020 to 2026
$2.2M
K24 Advancing Reproductive RheumatologyK24AR084072 · NIAMS · DUKE UNIVERSITY · PI Megan E.B. Clowse · 2024 to 2026
$472k
NIAMS NIH HHS K24 AR084072NICHD NIH HHS K12 HD103083
6 · The paper itself

Abstract

Background/PurposeThe B cell Activating Factor (BAFF) signaling pathway influences rheumatic disease through its role in the selection, maturation, and survival of B cells. Increased BAFF also correlates with hypertension and preeclampsia in pregnant women without rheumatic disease. We sought to correlate BAFF levels in pregnancy with pregnancy outcomes among women with rheumatic disease.MethodsBlood samples, disease activity assessments, labs, and pregnancy outcomes were prospectively collected from pregnant women with systemic lupus erythematosus (SLE). Inclusion criteria were enrollment prior to 30 weeks gestation and known pregnancy outcome. Preeclampsia diagnosis was determined through chart review and consensus among 6 providers (maternal-fetal medicine, nephrology, and rheumatology); pregnancies were excluded if a preeclampsia diagnosis could not be agreed upon. We assessed for changes in BAFF levels throughout pregnancy, and we investigated its association with disease activity and adverse pregnancy outcomes.ResultsThis study included 408 samples in 230 women with SLE (

Indexed as

B-Cell Activating FactorLupus Erythematosus, SystemicPre-EclampsiaPregnancy ComplicationsAdultFemaleHumansPregnancyPregnancy OutcomeProspective StudiesYoung AdultB-Cell Activating FactorTNFSF13B protein, humananti-DNA antibodiesPregnancyrenal lupussystemic lupus erythematosus

Identifiers

PMID41572585
PMCPMC13202497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.