Evidence map›Paper›PMID 41572421›Full record

ArticleActa neuropsychiatrica2026

A dual-marker peripheral signature of IL-6 elevation and

Cosmin Ioan Moga, Paul Adrian Chiroi, Livia Budișan, Octavia Oana Căpățînă, Cătălina Angela Crișan, Mihaela Fadgyas-Stănculete, Ioana Berindan-Neagoe, Ioana Valentina Micluția

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropsychiatrica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cosmin Ioan MogaNeurosciences, Iuliu Hațieganu University of Medicine and Pharmacyhttps://ror.org/051h0cw83, Romania.ORCID https://orcid.org/0000-0003-2521-1421
Paul Adrian ChiroiGenomics Department of MedFuture - Institute of Biomedical Research, Cluj-Napoca, Romania, Iuliu Hațieganu University of Medicine and Pharmacy, Romania.
Livia BudișanGenomics Department of MedFuture - Institute of Biomedical Research, Cluj-Napoca, Romania, Iuliu Hațieganu University of Medicine and Pharmacy, Romania.
Octavia Oana CăpățînăNeurosciences, Iuliu Hațieganu University of Medicine and Pharmacyhttps://ror.org/051h0cw83, Romania.
Cătălina Angela CrișanNeurosciences, Iuliu Hațieganu University of Medicine and Pharmacyhttps://ror.org/051h0cw83, Romania.
Mihaela Fadgyas-StănculeteNeurosciences, Iuliu Hațieganu University of Medicine and Pharmacyhttps://ror.org/051h0cw83, Romania.
Ioana Berindan-NeagoeGenomics Department of MedFuture - Institute of Biomedical Research, Cluj-Napoca, Romania, Iuliu Hațieganu University of Medicine and Pharmacy, Romania.
Ioana Valentina MicluțiaNeurosciences, Iuliu Hațieganu University of Medicine and Pharmacyhttps://ror.org/051h0cw83, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSchizophrenia (SCZ) shows marked biological heterogeneity, with negative symptoms linked to poor outcomes and hypothesised immune dysregulation. This study examined whether a peripheral cytokine-long non-coding RNA (lncRNA) panel could distinguish patients with SCZ and Brief Negative Symptom Scale (BNSS)-defined subgroups from healthy controls (HC).

methodsForty-one hospitalised patients with SCZ completed the BNSS and the Positive and Negative Syndrome Scale (PANSS). Twenty HCs, frequency-matched for age and sex, served as comparison samples. Severe negative-symptom subgroups were defined using two BNSS criteria: a broader (SNS1) and a more restrictive (SNS2) threshold. Serum cytokines - interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), interleukin-10 (IL-10) - and leukocyte lncRNAs (

resultsIL-6 correlated with PANSS Total (

conclusionsElevated IL-6 and decreased

Indexed as

Interleukin-6RNA, Long NoncodingSchizophreniaAdultBiomarkersCross-Sectional StudiesFemaleHumansInterleukin-10MaleMiddle AgedPsychiatric Status Rating ScalesTumor Necrosis Factor-alphaBiomarkersIL6 protein, humanInterleukin-10Interleukin-6NEAT1 long non-coding RNA, humanRNA, Long NoncodingTumor Necrosis Factor-alphaIL-6inflammationNEAT1Negative symptomsschizophrenia

Identifiers

PMID41572421
PMCPMC13130349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.