ArticleBMC research notes2026
Exploratory analysis of allostatic load and mortality in patients with hepatocellular carcinoma.
Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Association Between Allostatic Load, Genetic Susceptibility, and Liver Cancer Incidence: A Large-Scale Prospective Cohort Study.International journal of cancer · 2026Article
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4 authors.
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Abstract
objectiveHepatocellular carcinoma (HCC) disproportionately affects socially disadvantaged individuals. While tumor stage and liver function predict survival, biologic stress from chronic adversity, measured by allostatic load (AL), may provide additional prognostic insight. We aimed to evaluate the association between AL and mortality in patients with HCC and assess whether health literacy (HL) modifies this relationship.
resultsWe conducted a secondary analysis of 139 adults with HCC at two hospitals in Indianapolis (2019-2022). AL was calculated from six physiologic biomarkers, with scores ≥ 3 indicating high AL. HL and cumulative social disadvantage were measured using validated tools. Higher AL (HR 1.27; 95% CI 1.05-1.55) and lower HL (HR 1.83; 95% CI 1.10-3.05) were independently associated with mortality. After adjustment, AL remained significant but was attenuated when HL was included. Stratified analyses showed that AL predicted mortality only among patients with high HL. These exploratory findings suggest AL may help identify higher-risk patients, warranting validation in prospective, multi-center studies.
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