Evidence map›Paper›PMID 41572362›Full record

ArticleBMC research notes2026

Value of the systemic immuno-inflammatory index as a diagnostic tool for the main causes of knee pain presenting in the emergency department in Yaoundé, Cameroon.

Jan René Nkeck, Baudelaire Fojo, Xaverie Brenda Andela, Adeline Pelda, Stéphane Fargeon Massin Mbouna, Bernard Azanmene, Caroline Ngoufack-Tientcheu, Madeleine Ngandeu-Singwé

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Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jan René NkeckDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon. jrnkeck@gmail.com.
Baudelaire FojoDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Xaverie Brenda AndelaDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Adeline PeldaDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Stéphane Fargeon Massin MbounaDepartment of Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Bernard AzanmeneRheumatology unit, Yaoundé Central Hospital, Yaoundé, Cameroon.
Caroline Ngoufack-TientcheuDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
Madeleine Ngandeu-SingwéDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn a context of limited resources, differentiating the etiologies of knee pain in the emergency department can be challenging. Full blood count is one of the constantly available tests with many under-exploited indices, such as the systemic immuno-inflammatory index (SII). The present study aimed to assess its diagnostic value.

methodsA cross-sectional study was conducted from January to May 2024 on adults with a confirmed diagnosis of one of the three main causes of knee pain seen in the emergency department of Yaoundé Central Hospital. The SII (platelet count x neutrophil count/lymphocyte count) was compared between etiological groups using ANOVA. The ROC curve was used to determine its sensitivity (Se) and specificity (Sp) in differentiating these etiologies.

resultsThe three main causes were knee osteoarthritis flare (KOA; 126 cases), acute gouty arthritis (49 cases), and bacterial septic arthritis (SA; 25 cases). The SII differed significantly among the three groups: it was lower in KOA (mean 242, standard deviation 165) and higher in bacterial septic arthritis (mean 1234, standard deviation 557). An SII value below 271 allows differentiation between KOA and gout or SA (Se = 78%, Sp = 67%), while an SII value above 487 permits differentiation between gout and septic arthritis (Se = 95%, Sp = 75%).

conclusionThe SII is an interesting diagnostic tool for cases of knee pain seen in emergency departments. However, it would be appropriate to evaluate it on a larger sample before integration into the decision tree in a context of limited resources.

Indexed as

ArthralgiaArthritis, GoutyArthritis, InfectiousEmergency Service, HospitalKnee JointOsteoarthritis, KneeAdultAgedCameroonCross-Sectional StudiesDiagnosis, DifferentialFemaleHumansInflammationMaleMiddle AgedCameroonKnee painSystemic immuno-inflammatory index

Identifiers

PMID41572362
PMCPMC12911294

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.