Evidence map›Paper›PMID 41572344›Full record

ReviewCell communication and signaling : CCS2026

Bacterial outer membrane vesicles: a smart platform for biomedical applications.

Junbo Wang, Qisong Liu, Fuchao Huang, Shaogeng Wang, Chenxi Wu, Yang Chao, Shaokai Huang, Yujie Liang, Xiaohua Pan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Junbo WangDepartment of Orthopedics and Traumatology, People's Hospital of Shenzhen Baoan District, The Second Affiliated Hospital of Shenzhen University, Shenzhen, 518100, China.ORCID http://orcid.org/0009-0000-4787-6294
Qisong LiuDepartment of Orthopedics and Traumatology, People's Hospital of Shenzhen Baoan District, The Second Affiliated Hospital of Shenzhen University, Shenzhen, 518100, China.
Fuchao HuangDepartment of Orthopedics and Traumatology, Shenzhen Baoan School of Clinical Medicine, Guangdong Medical University, Shenzhen, 518100, China.
Shaogeng WangDepartment of Orthopedics and Traumatology, People's Hospital of Shenzhen Baoan District, The Second Affiliated Hospital of Shenzhen University, Shenzhen, 518100, China.
Chenxi WuDepartment of Orthopedics and Traumatology, People's Hospital of Shenzhen Baoan District, The Second Affiliated Hospital of Shenzhen University, Shenzhen, 518100, China.
Yang ChaoDepartment of Orthopedics and Traumatology, People's Hospital of Shenzhen Baoan District, The Second Affiliated Hospital of Shenzhen University, Shenzhen, 518100, China.
Shaokai HuangDepartment of Orthopedics and Traumatology, Shenzhen Baoan School of Clinical Medicine, Guangdong Medical University, Shenzhen, 518100, China.
Yujie LiangDepartment of Orthopedics and Traumatology, People's Hospital of Shenzhen Baoan District, The Second Affiliated Hospital of Shenzhen University, Shenzhen, 518100, China. liangyjie@126.com.ORCID http://orcid.org/0000-0002-0860-4859
Xiaohua PanDepartment of Orthopedics and Traumatology, People's Hospital of Shenzhen Baoan District, The Second Affiliated Hospital of Shenzhen University, Shenzhen, 518100, China. szpxh4141@foxmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Outer membrane vesicles (OMVs) are non-replicating, nanoscale particles naturally released by Gram-negative bacteria, which play important roles in bacterial communication and host interactions. Due to their biocompatibility, efficient production through fermentation, and inherent lymph node targeting capability, OMVs have emerged as a promising platform for biomedical applications, including vaccine development, drug delivery, immune modulation, cancer therapy, and antimicrobial strategies. This review discusses the biogenesis and biological functions of OMVs, methods for their isolation, and recent advances in their engineering as drug delivery systems, with a focus on vaccines and immunoadjuvants. We also address key challenges in scalable production and purification, propose potential solutions, and highlight current limitations along with future research directions.

Indexed as

Bacterial Outer MembraneGram-Negative BacteriaAnimalsDrug Delivery SystemsHumansBiomedical applicationsCancer therapyDrug deliveryGram-negative bacteriaImmunotherapyOuter membrane vesicles

Identifiers

PMID41572344
PMCPMC12918595

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.