Umbilical cord-derived mesenchymal stromal cells attenuate radiation-induced neuron damage in vitro.

Trang Thi Binh Pham, Kenshi Sei, Yuki Yamamoto, Takeo Mukai, Hiroyuki Akai, Tokiko Nagamura-Inoue

Abstract read

In one paragraph

Article in Stem cell research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Trang Thi Binh PhamDepartment of Cell Processing and Transfusion, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.

Kenshi SeiDepartment of Cell Processing and Transfusion, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.

Yuki YamamotoDepartment of Cell Processing and Transfusion, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.

Takeo MukaiDepartment of Cell Processing and Transfusion, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.

Hiroyuki AkaiDepartment of Radiology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.

Tokiko Nagamura-InoueDepartment of Cell Processing and Transfusion, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan. tokikoni@ims.u-tokyo.ac.jp.

Funding

AMED 23be0804004h0003Human Life Cord Japan Inc. joint research studyJSPS KAKENHI (Grant-in-Aid for Challenging Research (Exploratory) 23K17432

6 · The paper itself

Abstract

Radiation-induced brain injury is caused by repeated radiation therapy for brain tumors and leukemia. Effective treatments for radiation-induced brain injury have not been developed. This study aimed to investigate the neuroprotective effects of umbilical cord-derived mesenchymal stromal cells (UC-MSCs) on irradiated neurons. We irradiated fetal mouse cortical neurons followed by coculture with UC-MSCs in vitro. Radiation significantly reduced the number of MAP2-positive mature and GAP43-positive immature neurons with a shortened neurite length, whereas coculture with UC-MSCs significantly restored the number and length of both MAP2-positive and GAP43-positive neurons. Irradiation induced apoptosis/necrosis in neurons significantly, while UC-MSCs prevented the neurons from apoptosis to necrosis. The incidence of reactive oxygen species (ROS) increased significantly in irradiated neurons compared to the control group, whereas it was significantly attenuated by the coculture of UC-MSCs. In conclusion, these results suggest that UC-MSCs have potential neuroprotective effects against radiation-induced brain injury by reducing oxidative stress.

Indexed as

Mesenchymal Stem CellsNeuronsUmbilical CordAnimalsApoptosisCells, CulturedCoculture TechniquesHumansMiceOxidative StressReactive Oxygen SpeciesReactive Oxygen SpeciesBrain injuryMesenchymal stromal cellNeuroprotectionRadiation injuryUmbilical cord

Identifiers

PMID41572332

DOI10.1186/s13287-026-04907-8

PMCPMC12910956

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.