Evidence map›Paper›PMID 41572318›Full record

ArticleBMC research notes2026

Retention and longitudinal change in Insight 46, an intensive neuroscience sub-study of the 1946 British birth cohort.

Sarah E Keuss, Kirsty Lu, Sarah-Naomi James, Jennifer M Nicholas, William Coath, Ashvini Keshavan, David M Cash, Carole H Sudre, Josephine Barnes, Heidi Murray-Smith and 4 more

Abstract read
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In one paragraph

Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sarah E KeussDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 8-11 Queen Square, London, WC1N 3BG, UK.
Kirsty LuDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 8-11 Queen Square, London, WC1N 3BG, UK.
Sarah-Naomi JamesMRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK.
Jennifer M NicholasDepartment of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.
William CoathDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 8-11 Queen Square, London, WC1N 3BG, UK.
Ashvini KeshavanDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 8-11 Queen Square, London, WC1N 3BG, UK.
David M CashDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 8-11 Queen Square, London, WC1N 3BG, UK.
Carole H SudreDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 8-11 Queen Square, London, WC1N 3BG, UK.
Josephine BarnesDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 8-11 Queen Square, London, WC1N 3BG, UK.
Heidi Murray-SmithDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 8-11 Queen Square, London, WC1N 3BG, UK.
Andrew WongMRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK.
Rebecca StreetDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 8-11 Queen Square, London, WC1N 3BG, UK.
Marcus RichardsMRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK.
Jonathan M SchottDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 8-11 Queen Square, London, WC1N 3BG, UK. j.schott@ucl.ac.uk.

Funding

Alzheimer's Association SG-666374-UK BIRTH COHORTAlzheimer's Research UK ARUK-BBC2023-002National Institute for Health Research for DIADEM NIHR204280UK Research and Innovation MR/V03863X/1
6 · The paper itself

Abstract

objectivesParticipant retention is a significant challenge in ageing and dementia research. This analysis investigated (a) factors associated with retention in Insight 46, a neuroscience sub-study of the 1946 British birth cohort, and (b) clinical and cognitive changes over 2.5 years of follow-up.

resultsOf 502 participants assessed at baseline (mean[SD] age: 70.5[0.7] years), 442 returned for follow-up (mean[SD] interval: 2.5[0.3] years), representing a retention rate of 88%. Being β-amyloid positive (measures using positron emission tomography), female sex, and older age at baseline associated with lower odds of retention, while completion of neuroimaging and better cognitive performance at baseline- particularly on memory testing- related to higher odds of retention. By the time of follow-up, 14 participants were deceased, 12 of whom were female. Over follow-up, improvements were noted in certain cognitive tests (face-name test, logical memory delayed recall) with declines seen in others (mini-mental state examination, digit-symbol substitution test). Increases in self- and informant-reported cognitive complaints, cognitive disorder diagnoses, and motor abnormalities were also observed, alongside declines in blood pressure. These results have implications for the interpretation and generalisability of Insight 46 data and may be relevant to the planning of other longitudinal studies in this field.

Indexed as

AgingCognitionDementiaNeurosciencesAgedBirth CohortFemaleHumansLongitudinal StudiesMaleNeuropsychological TestsUnited KingdomAgeingAttritionBirth cohortLongitudinalNeurosciencePopulationRetention

Identifiers

PMID41572318
PMCPMC12837026

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.