Evidence map›Paper›PMID 41572265›Full record

ArticleBMC biology2026

TPST2-mediated tyrosine sulfation orchestrates porcine preimplantation development.

Jiaze Gao, Chengpeng Wang, Hongshuang Xie, Guang Yang, Qingbo Yang, Cheng Huang, Shijie Li, Zhonghua Liu, Tianyao He, Zhi Yin and 2 more

Abstract read
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In one paragraph

Article in BMC biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiaze Gao *Key Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin, 150030, China.
Chengpeng Wang *Key Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin, 150030, China.
Hongshuang Xie *Key Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin, 150030, China.
Guang YangKey Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin, 150030, China.
Qingbo YangKey Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin, 150030, China.
Cheng HuangKey Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin, 150030, China.
Shijie LiKey Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin, 150030, China.
Zhonghua LiuKey Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin, 150030, China. liuzhonghua@neau.edu.cn.
Tianyao HeKey Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin, 150030, China. hetianyao@neau.edu.cn.
Zhi YinKey Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin, 150030, China. zyin@neau.edu.cn.
Jun-Xue JinKey Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin, 150030, China. jinjunxue@neau.edu.cn.
Jiaqiang WangKey Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin, 150030, China. wangjiaqiang@neau.edu.cn.

Funding

National Key Research and Development Program of China 2024YFA1802403National Natural Science Foundation of China 32402761National Natural Science Foundation of China 32470860Postdoctoral Fellowship Program of CPSF GZB20240132
6 · The paper itself

Abstract

backgroundTyrosine sulfation is a widespread posttranslational modification in mammals and is known to influence protein function and signaling. However, its functional significance during porcine preimplantation development remains poorly understood.

resultsIn this study, we demonstrate that TPST2-mediated tyrosine sulfation is critical for early porcine embryonic development. TPST2 is transcriptionally activated during zygotic genome activation by its antisense long noncoding RNA, termed aTPST2, which recruits MED4, a core subunit of the Mediator complex, to activate TPST2 transcription in cis. Mechanistically, TPST2 mediates sulfation at tyrosine 39 (Y39) of TTYH3, enhancing its protein stability. The stabilized TTYH3 interacts with RAP1B to activate MAPK signaling, thereby ensuring proper embryonic development.

conclusionsOur findings elucidate a compelling molecular mechanism by which tyrosine sulfation orchestrates porcine preimplantation development. Together, these results provide new insights into the developmental functions of tyrosine sulfation.

Indexed as

BlastocystEmbryonic DevelopmentSulfotransferasesTyrosineAnimalsFemaleGene Expression Regulation, DevelopmentalSwineSulfotransferasesTyrosineLncRNA aTPST2Porcine preimplantation developmentSulfated TTYH3TPST2Tyrosine sulfation

Identifiers

PMID41572265
PMCPMC12910770

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.