ArticleBMC genomics2026
Comparative analysis of brain transcriptomics, intestinal metabolomics and intestinal microbial diversity between two body weight-differentiated groups of mandarin fish (Siniperca chuatsi) after artificial feed acclimation.
Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundAfter feeding carnivorous mandarin fish (Siniperca chuatsi) with formulated feed, obvious phenotypic differences in body weight and other traits were observed in the fish. Comparative analyses were conducted on the brain tissue transcriptome, intestinal metabolomics, and intestinal microbial diversity of the two groups with body weight differences, aiming to explore whether such differences are associated with individual gene expression levels, metabolic pathways, and intestinal microbiota.
resultsCompared to the easy-acclimation group (EA), the difficult-acclimation group (DA) exhibited significantly lower body weight and length (P < 0.05). Brain transcriptome analysis identified 1478 differentially expressed genes (DEGs), with key anorexigenic genes mc4r, htr1b, and lgr4 significantly upregulated in the DA group. KEGG enrichment analysis showed activation of pathways such as neuroactive ligand-receptor interaction. Metabolomics revealed a significant reduction of six key neuro-nutritional metabolites, including pyridoxine (vitamin B6), L-carnosine, and anserine in the DA group’s gut (|FC| > 5, P < 0.05), indicating impeded metabolic pathways. Correspondingly, the intestinal microbiota of group DA exhibited reduced diversity, dominated by genera such as Clostridium, Latilactobacillus, and Cetobacterium, whereas the EA group was enriched with beneficial genera like Megasphaera, Sanguibacter, and Muribaculum. Furthermore, correlation analysis revealed close associations between brain feeding genes, gut metabolites, and microbiota structure.
conclusionThe results of this study indicate that the observed differences in growth performance post-acclimation are associated with the synergistic regulation of brain gene expression, host metabolites, and intestinal microbiota. These results elucidate key molecular mechanisms in the acclimation process of mandarin fish.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.