Evidence map›Paper›PMID 41572047›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026

Cognitive impairment is associated with altered blood cell profiles in aggressive lymphoma.

Delyse McCaffrey, Priscilla Gates, Haryana M Dhillon, Carlene Wilson, Janette L Vardy, Cynthia Shannon Weickert, Adam K Walker

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Delyse McCaffrey *Laboratory of ImmunoPsychiatry, Neuroscience Research Australia, Randwick, NSW, Australia.
Priscilla Gates *Cognitive Neuroscience Lab, School of Psychology, Deakin University, Burwood, VIC, Australia.
Haryana M DhillonFaculty of Science, School of Psychology, Psycho-Oncology Cooperative Research Group, The University of Sydney, Sydney, NSW, Australia.
Carlene WilsonCentre for Epidemiology and Biostatistics, Monash School of Population and Global Health, the University of Melbourne, Melbourne, VIC, Australia.
Janette L VardyFaculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.
Cynthia Shannon WeickertDiscipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Adam K WalkerLaboratory of ImmunoPsychiatry, Neuroscience Research Australia, Randwick, NSW, Australia. a.walker@neura.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCognitive and psychological symptoms in neuropsychiatric disorders have been linked to blood cell parameters, including neutrophil-to-lymphocyte ratios (NLRs), systemic immune-inflammation indices (SIIs), and platelet-to-lymphocyte ratios (PLRs). It remains unclear whether cognitive impairments in haematological cancers are associated with biological vulnerabilities reflected in these parameters. We examined whether cognitive and psychological morbidity correlated with blood cell parameters before, during, and after chemotherapy in individuals with aggressive lymphoma.

methodsNeuropsychological testing and self-reported questionnaires were administered at diagnosis, mid-chemotherapy, and 6-8 weeks post-treatment (n = 30). Regression models assessed associations between cognition and blood cell parameters. Bootstrapped Pearson correlations examined relationships between NLRs, SIIs, PLRs, and psychological symptoms. To test specificity, similar analyses were conducted in healthy controls (n = 72).

resultsIn individuals with aggressive lymphoma, NLRs, SIIs, and PLRs correlated with impairments in inhibitory control, cognitive flexibility, delayed recall, and working memory across time points (p < 0.05). A disconnect emerged between these parameters and subjective self-reports. At diagnosis, lower NLRs, SIIs, and PLRs were associated with worse objective cognitive performance but better perceived cognition. Mid-chemotherapy, higher NLRs correlated with worse delayed recall but fewer reported depression and anxiety symptoms (p < 0.05). No significant associations were observed in healthy controls.

conclusionCognitive impairment was associated with blood cell parameters in individuals with aggressive lymphoma, indicating distinct biological patterns of dysfunction before, during, and after chemotherapy. The disconnect between objective neuropsychological performance and subjective self-reports reinforces the value of incorporating biomarkers into cognitive assessments in this population.

Indexed as

Cognitive DysfunctionLymphomaAdultAgedAntineoplastic AgentsCase-Control StudiesFemaleHumansInflammationLymphocytesMaleMiddle AgedNeuropsychological TestsNeutrophilsSelf ReportSurveys and QuestionnairesAntineoplastic AgentsAnxietyChemotherapyCognitive impairmentDepressionExecutive functionInflammationLymphomaNeutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratioSystemic immune-inflammation index

Identifiers

PMID41572047
PMCPMC12827377

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.