Evidence map›Paper›PMID 41572044›Full record

ArticleEuropean radiology2026

Regulation of brain iron homeostasis and its influence on cognitive function.

Sujung Yoon, Yoonji Joo, Eunji Ha, Suji Lee, Chaewon Suh, Yumi Song, Haejin Hong, Youngeun Shim, Yejin Kim, Hyeonji Lee and 3 more

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In one paragraph

Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Sujung Yoon *Ewha Brain Institute, Ewha Womans University, Seoul, South Korea.
Yoonji Joo *Ewha Brain Institute, Ewha Womans University, Seoul, South Korea.
Eunji HaEwha Brain Institute, Ewha Womans University, Seoul, South Korea.
Suji LeeDivision of Psychology and Cognitive Science, Seoul Women's University, Seoul, South Korea.
Chaewon SuhEwha Brain Institute, Ewha Womans University, Seoul, South Korea.
Yumi SongEwha Brain Institute, Ewha Womans University, Seoul, South Korea.
Haejin HongEwha Brain Institute, Ewha Womans University, Seoul, South Korea.
Youngeun ShimEwha Brain Institute, Ewha Womans University, Seoul, South Korea.
Yejin KimEwha Brain Institute, Ewha Womans University, Seoul, South Korea.
Hyeonji LeeEwha Brain Institute, Ewha Womans University, Seoul, South Korea.
Hyeonseok JeongEwha Brain Institute, Ewha Womans University, Seoul, South Korea.
Soo Mee LimDepartment of Radiology, College of Medicine, Ewha Womans University, Seoul, South Korea.
In Kyoon LyooEwha Brain Institute, Ewha Womans University, Seoul, South Korea. inkylyoo@ewha.ac.kr.ORCID http://orcid.org/0000-0002-9717-1935

Funding

National Research Foundation of Korea NRF-2020R1A6A1A03043528National Research Foundation of Korea RS-2024-00345975National Research Foundation of Korea RS-2024-00457381
6 · The paper itself

Abstract

objectivesIron is essential for oxygen transport and neuronal integrity, underscoring the importance of maintaining iron homeostasis for optimal brain function. This study aimed to elucidate the interplay among systemic iron status, brain iron levels, and cerebral blood flow (CBF), with a particular focus on their influence on cognitive performance. MATERIALS AND

methodsA total of 332 healthy women without a history of iron-related disorders were recruited and stratified into three groups based on serum iron concentrations: low-iron, reference, and high-iron groups. Brain iron content and CBF were assessed in the basal ganglia (BG) using quantitative susceptibility mapping and arterial spin labeling perfusion-weighted imaging, respectively. Cognitive performance was evaluated using attention-focused assessments.

resultsAlthough the low-iron group exhibited systemic iron deficiency, BG susceptibility values did not significantly differ from those of the reference group (p = 0.13). Path analysis revealed that lower blood iron levels were significantly associated with reduced BG susceptibility (p < 0.001), and that both lower blood iron (p < 0.001) and reduced susceptibility (p = 0.01) were associated with increased BG CBF. Decreased blood iron was associated with impaired attention performance, and a curvilinear relationship was observed between BG susceptibility and attention performance.

conclusionThese findings indicate a dynamic interaction between systemic and brain iron homeostasis, which influences BG CBF and attention performance. KEY POINTS: Question What are the associations among blood iron levels, brain iron content, cerebral blood flow (CBF), and attention performance in healthy women? Findings Reduced systemic and brain iron levels were significantly associated with elevated CBF. Variability in both iron levels was linked to alterations in attention performance. Clinical relevance The observed associations between systemic and brain iron status and cognitive performance highlight the importance of maintaining blood-brain iron homeostasis to prevent cognitive dysfunction, particularly in individuals with iron deficiency.

Indexed as

BrainCognitionHomeostasisIronAdultCerebrovascular CirculationFemaleHumansMagnetic Resonance ImagingMiddle AgedIronArterial spin labelingBrain iron homeostasisCerebral blood flowCognitive functionQuantitative susceptibility mapping

Identifiers

PMID41572044
PMCPMC13212747

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.