Evidence map›Paper›PMID 41571987›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

A dual role of hippocampal perineuronal nets in plasticity and protection is revealed by improvement and impairment of diet-induced memory dysfunction.

Amy C Reichelt, Ahmed M Hashad, Olivia R Ghosh-Swaby, Miguel Skirzewski, Gavin A Scott, Meira Machado, Cecilia P Kramar, Oren Princz-Lebel, Wataru Inoue, Timothy J Bussey and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amy C ReicheltDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Ahmed M HashadDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Olivia R Ghosh-SwabyRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, On, Canada. oghoshsw@uwo.ca.
Miguel SkirzewskiRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, On, Canada.
Gavin A ScottRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, On, Canada.
Meira MachadoRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, On, Canada.ORCID http://orcid.org/0000-0003-4619-5782
Cecilia P KramarDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Oren Princz-LebelDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Wataru InoueDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0002-2438-5123
Timothy J BusseyDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0002-3180-3709
Lisa M SaksidaDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0002-8416-8171

Funding

Department of Education and Training | Australian Research Council (ARC) DP180101974
6 · The paper itself

Abstract

Alterations to perineuronal nets (PNNs) are linked to cognitive deficits observed in multiple neuropsychiatric and neurodegenerative conditions. PNNs are proposed both to limit neuronal plasticity and to protect neuronal populations critical for cognitive function. Here, we assessed these two distinct proposed functions of PNNs in the same experimental procedure, varying only the timing of PNN manipulation. Enzymatic degradation of hippocampal PNNs 4 weeks after an obesogenic high-fat high-sugar (HFHS) diet - which causes hippocampal-dependent memory impairments - restored memory performance, demonstrating a key role of PNNs in plasticity. In contrast, degradation of hippocampal PNNs prior to HFHS diet exacerbated memory deficits, demonstrating PNNs' role in neuroprotection. Because PNNs primarily surround PV

Indexed as

Diet, High-FatHippocampusMemory DisordersNeuronal PlasticityPerineuronal NetsAnimalsMaleMiceMice, Inbred C57BL

Identifiers

PMID41571987
PMCPMC13212925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.