Genome mining discovery of aquimarinols, threoninol-containing acylpeptides from Aquimarina muelleri.

Abstract read

In one paragraph

Article in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zhihan ZhangZhejiang Key Laboratory of Precise Synthesis of Functional Molecules, Department of Chemistry, School of Science, Westlake University, 600 Dunyu Rd., Hangzhou, 310030, Zhejiang Province, China.

Lihan ZhangZhejiang Key Laboratory of Precise Synthesis of Functional Molecules, Department of Chemistry, School of Science, Westlake University, 600 Dunyu Rd., Hangzhou, 310030, Zhejiang Province, China. zhanglihan@westlake.edu.cn.ORCID http://orcid.org/0000-0003-4364-6242

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22177092

6 · The paper itself

Abstract

Thioester reductase domain in nonribosomal peptide synthetases catalyzes reductive offloading to produce aldehyde- or alcohol-containing peptides. By genome mining focusing on thioester reductase domains, we isolated aquimarinols A-D, four novel polyketide-peptide hybrid metabolites isolated from the sponge-derived strain Aquimarina muelleri LMG 22569. Structural elucidation of aquimarinols revealed a β-formamidated fatty acid (FA) moiety and a threoninol unit linked by a peptide bond or an ester bond. The biosynthesis of aquimarinols is proposed to proceed via a hybrid trans-AT polyketide synthase-nonribosomal peptide synthetase pathway coupled with modification enzymes.

Indexed as

PeptidesPoriferaAnimalsPeptide SynthasesPolyketidesPeptidesPeptide SynthasesPolyketides

Identifiers

PMID41571983

DOI10.1038/s41429-026-00894-3

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.