ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2026
What constitutes important change in individual PROMIS-10 global health items in patients with high-impact chronic pain: a qualitative interview study.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeHealth-related quality of life is a key outcome for patients with high-impact chronic pain, and the PROMIS-10 Global Health questionnaire is widely used to assess it. This study examined what patients perceive as important changes in PROMIS-10 Global Health items by 1) 1) examining how much each item should change to be perceived as important, and 2) exploring why and how these changes were considered important.
methodsIndividual semi-structured interviews with 17 participants with high-impact chronic pain were conducted. Analysis for objective one involved determining item-level thresholds for important change by aggregating participants’ reported change scores for each item. Analysis for objective two involved thematic analysis to explore how and why such changes were perceived as important.
resultsFor items rated on a 5-point Likert scale, change scores perceived as important ranged from a mean of 1.09 (median = 1) for item 1 (general health) to a mean of 1.84 (median = 2) for item 8r (fatigue). For item 7r (pain intensity), rated on a 0–10 scale, a mean change score of 4.36 (median = 4.25) was considered important. Thematic analysis identified one to two themes per item, reflecting perceived important improvement across physical, mental, and social health.
conclusionThis is the first qualitative study to explore what patients with high-impact chronic pain perceive as important changes in PROMIS-10 Global Health items. Findings reflect important improvements across physical, mental, and social health, highlighting the value of patient perspectives in clinical use. Further qualitative research is needed to enhance interpretation and inform clinical applications.
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