Evidence map›Paper›PMID 41571784›Full record

ArticleEuropean journal of pediatrics2026

Gastrointestinal endoscopic evaluation and management in neonates: a 10-Year clinical experience.

Jiexia Gao, Yuling Feng, Kai Lin, Ling Wang, Xing Wang, Weiwei Cheng, Zhujun Gu, Haifeng Liu, Cheng Cai

Abstract read
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In one paragraph

Article in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiexia GaoDepartment of Gastroenterology II, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Yuling FengDepartment of Gastroenterology II, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Kai LinDepartment of Gastroenterology II, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Ling WangDepartment of Gastroenterology II, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Xing WangDepartment of Gastroenterology II, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Weiwei ChengDepartment of Gastroenterology II, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Zhujun GuDepartment of Gastroenterology II, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Haifeng LiuDepartment of Gastroenterology II, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China. haifengliush@aliyun.com.
Cheng CaiDepartment of Neonatology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China. caicheng2004@163.com.

Funding

Shanghai Hospital Development Center Foundation SHDC12024114
6 · The paper itself

Abstract

Gastrointestinal endoscopy is rarely performed in neonates due to concerns regarding safety and technical feasibility. This study aimed to evaluate its safety, feasibility, and diagnostic yield, and to explore its role as both a diagnostic and therapeutic tool in neonatal gastrointestinal diseases. This retrospective study included 42 neonates, both preterm and term, who underwent gastrointestinal endoscopy at Shanghai Children's Hospital between 2015 and 2025. Indications for endoscopy, endoscopic findings, therapeutic approaches and follow-up outcomes were analyzed. All neonates underwent successful gastroscopy, including 4 who also received colonoscopy. The cohort included both term and preterm infants. The most common indication was gastrointestinal bleeding, particularly hematemesis. In preterm neonates, the primary indications were feeding intolerance and the need for enteral nutritional support. Abnormal endoscopic findings were identified in over 85.7% of infants, including mucosal erosion, ulcer, hemorrhagic lesion, congenital or acquired mechanical obstruction and inflammation. Endoscopic interventions included topical hemostatic therapy, nasojejunal tube placement, and balloon dilation. No procedure-related complications such as perforation, respiratory deterioration were observed.

conclusionsWith ongoing advances in gastrointestinal endoscopy and increasing clinical experience, its use in neonates has expanded. In some cases, endoscopy serves as an adjunct to diagnostic evaluation and therapeutic management. WHAT IS KNOWN: • Gastrointestinal endoscopy is rarely performed in neonates due to technical limitations and concerns regarding safety. • Most existing studies involve small case series, offering limited data on diagnostic yield and therapeutic potential. WHAT IS NEW: • A 10-year clinical cohort demonstrates that endoscopy is safe and feasible in both term and preterm neonates using ultrathin instruments. • Endoscopy provides substantial diagnostic value for diverse neonatal gastrointestinal conditions and enables targeted therapeutic interventions, including topical hemostatic therapy, Nasojejunal tube placement, and balloon dilation.

Indexed as

Endoscopy, GastrointestinalGastrointestinal DiseasesChinaFeasibility StudiesFemaleGastrointestinal HemorrhageHumansInfant, NewbornInfant, PrematureMaleRetrospective StudiesDiagnosisEndoscopic TherapyGastrointestinal EndoscopyNeonate

Identifiers

PMID41571784

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.