Evidence map›Paper›PMID 41571750›Full record

ArticleScientific reports2026

Identification of a novel natural compound that acts on the membrane progestin receptor α (paqr7) from the marine algae Padina.

Mohammad Tohidul Amin, Shinya Kodani, Hiroyuki Nakagawa, Tomohiro Furukawa, Saokat Ahamed, Abdullah An Naser, Koki Yamaguchi, Yuki Omori, Shakhawat Hossain, Mohammad Maksudul Hassan and 1 more

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mohammad Tohidul AminDepartment of Bioscience, GraduateSchool of Science and Technology, National University Corporation, Shizuoka University, 836 Ohya, Suruga-Ku, Shizuoka, 422-8529, Japan.
Shinya KodaniDepartment of Bioscience, GraduateSchool of Science and Technology, National University Corporation, Shizuoka University, 836 Ohya, Suruga-Ku, Shizuoka, 422-8529, Japan.
Hiroyuki NakagawaResearch Center for Advanced Analysis, Core Technology Research Headquarters, National Agriculture and Food Research Organization (NARO), 2-1-12 Kannondai, Tsukuba, Ibaraki, 305-8642, Japan.
Tomohiro FurukawaInstitute of Food Research, National Agriculture and Food Research Organization (NARO), 2-1-12 Kannondai, Tsukuba, Ibaraki, 305-8642, Japan.
Saokat AhamedDepartment of Bioscience, GraduateSchool of Science and Technology, National University Corporation, Shizuoka University, 836 Ohya, Suruga-Ku, Shizuoka, 422-8529, Japan.
Abdullah An NaserDepartment of Bioscience, Faculty of Science, Shizuoka University, Shizuoka, 422-8529, Japan.
Koki YamaguchiDepartment of Bioscience, Faculty of Science, Shizuoka University, Shizuoka, 422-8529, Japan.
Yuki OmoriBiological Science Course, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, 836 Ohya, Suruga-Ku, Shizuoka, 422-8529, Japan.
Shakhawat HossainDepartment of Bioscience, GraduateSchool of Science and Technology, National University Corporation, Shizuoka University, 836 Ohya, Suruga-Ku, Shizuoka, 422-8529, Japan.
Mohammad Maksudul HassanDepartment of Bioscience, GraduateSchool of Science and Technology, National University Corporation, Shizuoka University, 836 Ohya, Suruga-Ku, Shizuoka, 422-8529, Japan.
Toshinobu TokumotoDepartment of Bioscience, GraduateSchool of Science and Technology, National University Corporation, Shizuoka University, 836 Ohya, Suruga-Ku, Shizuoka, 422-8529, Japan. tokumoto.toshinobu@shizuoka.ac.jp.

Funding

Japan Society for the Promotion of Science 23K05830
6 · The paper itself

Abstract

Previously, we identified water-soluble compounds with membrane progestin receptor α (mPRα)-binding activity from the marine algae Padina arborescens. The compounds inhibited fish oocyte maturation. These compounds are potentially novel antagonists of mPR and are of interest as novel inhibitors of the nongenomic pathway of steroids. In this study, a compound with mPRα binding activity was purified from the methanol extract of Padina tarries. The structure of one of the major compounds in the fraction was identified as 1-carboxybutyl-2-hydroxypentanoate (1-CB 2-HPNA) using nuclear magnetic resonance spectroscopy and ESI-MS analysis. 1-CB 2-HPNA showed substantial competitive binding affinity for human mPRα (hmPRα) in the graphene quantum dot (GQD)-hmPRα binding assay. The physiological activity of 1-CB 2-HPNA was then evaluated using an in vitro and in vivo zebrafish oocyte maturation and ovulation assay. 1-CB 2-HPNA inhibited the maturation and ovulation of fish oocytes. In addition, 1-CB 2-HPNA inhibited ovulation in mice. These results indicate that 1-CB 2-HPNA, identified from Padina arborescens, is a novel natural mPRα antagonist.

Indexed as

Receptors, ProgesteroneRhodophytaAnimalsFemaleHumansMiceOocytesOvulationReceptors, G-Protein-CoupledZebrafishPAQR7 protein, humanReceptors, G-Protein-CoupledReceptors, Progesterone

Identifiers

PMID41571750
PMCPMC12901071

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.