Evidence map›Paper›PMID 41571702›Full record

ArticleScientific reports2026

Genomic risk prediction of type 2 diabetes in people living with and without HIV.

Nicole D Armstrong, Vinodh Srinivasasainagendra, Lavanya Pilla, Radhika Gangaraju, Peter W Hunt, Robin M Nance, Heidi M Crane, Inga Peter, Sonya L Heath, Greer A Burkholder and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Nicole D ArmstrongDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA. nmda@uab.edu.
Vinodh SrinivasasainagendraDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Lavanya PillaDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Radhika GangarajuDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Peter W HuntDivision of Experimental Medicine, University of California, San Francisco, San Francisco, CA, USA.
Robin M NanceDepartment of Medicine, University of Washington, Seattle, WA, USA.
Heidi M CraneDepartment of Medicine, University of Washington, Seattle, WA, USA.
Inga PeterDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sonya L HeathDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Greer A BurkholderDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Richard D MooreDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Jeffrey M JacobsonDepartment of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Edward R CachayDepartment of Medicine, Division of Infectious Diseases, Mayo Clinic, Scottsdale, AZ, USA.
Thibaut Davy-MendezSchool of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Hirotaka IwakiCenter for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.
Lana SargentCenter for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.
Hemant K TiwariDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Marguerite R IrvinDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Cardiorenal Genomics for Risk Prediction in African Descent PopulationsR35HL155466 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Marguerite R Irvin · 2021 to 2026
$5.1M
Pharmacogenomics and Systems Pharmacology Approaches to Toxicity, Tolerability, and Comorbidities Associated with Modern Antiretroviral TherapiesR01HG010649 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CRANE, HEIDI M., PETER, INGA · 2019 to 2023
$4.5M
Immunologic and Fat-Associated Predictors of Insulin Resistance in Treated HIVR01DK112304 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUNT, PETER W, KOLIWAD, SUNEIL KRISHNA · 2017 to 2021
$4.1M
Impact of Asymptomatic CMV on Cardiovascular Event Risk in Treated HIVR01HL180319 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUNT, PETER W · 2025 to 2025
$3.0M
Genomic approaches to cardiometabolic risk and treatment in HIVR01HL125027 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CRANE, HEIDI M., PETER, INGA · 2014 to 2017
$2.9M
Genome wide SNP analysis in Parkinson's diseaseZ01AG000949 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW B · 2006 to 2008
$2.6M
Genetic underpinnings of cardiorenal risk in Africans and African AmericansR01HL136666 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI IRVIN, MARGUERITE R, LANGE, LESLIE A · 2017 to 2020
$2.6M
Assessing the Interrelationship Between Adipose Tissue Thermogenesis and Fibrosis in the Metabolic Health of People Living with HIVR01DK141041 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PETER W HUNT, SUNEIL Krishna KOLIWAD · 2024 to 2026
$2.3M
UAB Institutional Career Development Program in HIV-Related Heart, Lung, Blood and ResearchK12HL143958 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HEATH, SONYA L · 2018 to 2022
$1.6M
Shared and novel contributors to risk of stroke and stroke recurrence in a multiethnic population – the role of social determinants of health, genetics, and epigeneticsR01NS136542 · NINDS · UNIVERSITY OF VIRGINIA · PI HSU, FANG-CHI, KEENE, KEITH L · 2024 to 2025
$1.2M
Intramural NIH HHS Z01 AG000949National Institute of Allergy and Infectious Diseases R24AI067039NHGRI NIH HHS R01 HG010649NHGRI NIH HHS R01HG010649NHLBI NIH HHS K01 HL169020NHLBI NIH HHS K08 HL159290NHLBI NIH HHS K08HL159290NHLBI NIH HHS K12 HL143958NHLBI NIH HHS K12HL143958NHLBI NIH HHS R01 HL125027NHLBI NIH HHS R01HL125027NHLBI NIH HHS R01 HL136666NHLBI NIH HHS R01HL136666NHLBI NIH HHS R01 HL180319NHLBI NIH HHS R35 HL155466NIAID NIH HHS P30 AI050410NIAID NIH HHS R24 AI067039NIA NIH HHS ZO1 AG000949NIDDK NIH HHS R01 DK112304NIDDK NIH HHS R01 DK141041NIDDK NIH HHS R56 DK133997NINDS NIH HHS R01 NS136542
6 · The paper itself

Abstract

Type 2 diabetes (T2D) risk prediction remains a challenge, particularly in underrepresented populations, including people living with HIV (PWH) and those of non-European ancestry. We evaluated the performance of two metaPRS (polygenic risk score) models, integrating genetic markers related to inflammation and lipid metabolism, in predicting T2D risk across ancestry groups (African and European), with and without HIV. The metaPRS were generated in a subset from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study (6,034 Black; 11,972 White) and validated in 7,580 (4,120 Black; 3,460 White) PWH from the Centers for AIDS Research of Integrated Clinical Systems (CNICS), as well as an additional 4,152 (2,586 Black; 1,566 White) seronegative participants from REGARDS. Incorporating the metaPRS into models provided non-significant improvements in T2D risk prediction compared to single-trait T2D PRS and clinical risk factors. Performance was similar in PWH and in people without HIV, suggesting that these general population-derived genetic scores are transferable to PWH. Future studies should focus on refining PRS models in diverse populations and exploring genetic factors specific to PWH regarding T2D risk.

Indexed as

Diabetes Mellitus, Type 2Genetic Predisposition to DiseaseHIV InfectionsAdultAgedBlack PeopleFemaleGenomicsHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk AssessmentRisk FactorsWhite PeopleHIVPolygenic risk scorePrecision medicineType 2 diabetes

Identifiers

PMID41571702
PMCPMC12830814

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.