Evidence map›Paper›PMID 41571700›Full record

ArticleScientific reports2026

Attenuation of biofilm-encoding genes and virulence attributes in clinical isolates of Acinetobacter baumannii by essential oil derived from Myroxylon balsamum.

Naji Naseef Pathoor, Pitchaipillai Sankar Ganesh, Rajesh Kanna Gopal, Abdul R Anshad, Esaki M Shankar, Vanitha Mariappan, Siddhardha Busi, Simi Asma Salim, Nachammai Kathiresan, Langeswaran Kulanthaivel and 4 more

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Naji Naseef PathoorQuorum Sensing and Biofilm Research Laboratory, Centre for Infectious Diseases, Department of Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University (Deemed to be University), Chennai, 600 077, Tamil Nadu, India.
Pitchaipillai Sankar GaneshQuorum Sensing and Biofilm Research Laboratory, Centre for Infectious Diseases, Department of Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University (Deemed to be University), Chennai, 600 077, Tamil Nadu, India. p_sankarganesh@hotmail.com.
Rajesh Kanna GopalQuorum Sensing and Biofilm Research Laboratory, Centre for Infectious Diseases, Department of Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University (Deemed to be University), Chennai, 600 077, Tamil Nadu, India.
Abdul R AnshadInfection and Inflammation, Department of Biotechnology, School of Integrative Biology, Central University of Tamil Nadu, Thiruvarur, 610 005, Tamil Nadu, India.
Esaki M ShankarInfection and Inflammation, Department of Biotechnology, School of Integrative Biology, Central University of Tamil Nadu, Thiruvarur, 610 005, Tamil Nadu, India.
Vanitha MariappanBiomedical Science Program, Center for Toxicology and Health Risk Studies (CORE), Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, 50300, Malaysia. vanitha.ma@ukm.edu.my.
Siddhardha BusiDepartment of Microbiology, School of Life Sciences, Pondicherry University, Kalapet, 605 014, Puducherry, India.
Simi Asma SalimDepartment of Microbiology, School of Life Sciences, Pondicherry University, Kalapet, 605 014, Puducherry, India.
Nachammai KathiresanDepartment of Biotechnology, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India.
Langeswaran KulanthaivelDepartment of Biomedical Science, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India.
Ramatchandirane MaheshDepartment of Biochemistry and Molecular Biology, Pondicherry University, Kalapet, 605 014, Puducherry, India.
Parthiban RudrapathyDepartment of Microbiology, Malabar Cancer Center, Thalassery, 670 103, Kerala, India.
Esaki Muthu PonmalarDepartment of Human Anatomy, Sri Sairam Siddha Medical College and Research Centre, Chennai, 600 044, Tamil Nadu, India.
Kitlangki SuchiangDepartment of Biochemistry, North Eastern Hill University, Shillong, 793 022, Meghalaya, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biofilm-associated infections due to recalcitrant bacterial pathogens pose a major challenge to global public health. Acinetobacter baumannii (A. baumannii) a multidrug-resistant bacterial pathogen, relies on biofilm formation and quorum sensing (QS) for sustained virulence and survival in the host. Here, we evaluated the anti-biofilm and anti-virulence potential of Myroxylon balsamum essential oil (M. balsamum EO) against A. baumannii (MCC-AB-07). M. balsamum EO disrupted biofilm formation, inhibited swarming motility, and increased bacterial susceptibility to oxidative stress. Our RT-qPCR investigations confirmed downregulation of key biofilm and QS genes. Additionally, M. balsamum EO resulted in improved survival of Caenorhabditis elegans following infection. Our findings indicate promising anti-biofilm and anti-virulence properties of M. balsamum EO, warranting elaborate investigations to explore its therapeutic applications and possible synergistic and complementary effects in conjunction with antibiotics.

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsBiofilmsOils, VolatileAcinetobacter InfectionsAnimalsCaenorhabditis elegansHumansOxidative StressQuorum SensingVirulenceAnti-Bacterial AgentsOils, VolatileAcinetobacter baumanniiBiofilmCaenorhabditis elegansEssential oilMyroxylon balsamumVirulence

Identifiers

PMID41571700
PMCPMC12827281

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.