SN/VTA neuromelanin signal is associated with subclinical paranoia irrespective of familial risk for psychosis.

Rami Hamati, Nour Kanaa, Bianca Chidiac, Synthia Guimond, Clifford Cassidy, Lauri Tuominen

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Article in Schizophrenia (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Rami HamatiUniversity of Ottawa's Institute of Mental Health Research at The Royal, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0001-7213-9253

Nour KanaaUniversity of Ottawa's Institute of Mental Health Research at The Royal, Ottawa, ON, Canada.

Bianca ChidiacUniversity of Ottawa's Institute of Mental Health Research at The Royal, Ottawa, ON, Canada.

Synthia GuimondUniversity of Ottawa's Institute of Mental Health Research at The Royal, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0002-1582-725X

Clifford CassidyUniversity of Ottawa's Institute of Mental Health Research at The Royal, Ottawa, ON, Canada.

Lauri TuominenUniversity of Ottawa's Institute of Mental Health Research at The Royal, Ottawa, ON, Canada. ltuominen@theroyal.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subclinical paranoia is present in the relatives of patients with psychosis but it is also relatively common in the general population. Dopamine neurotransmission is increased in people with psychosis and is linked with positive symptoms, such as paranoia. Here, we examined if neuromelanin-sensitive MRI, a proxy of long-term dopamine turnover, is different between those with (n = 25) and without (n = 77) a first-degree relative with psychosis (N = 102). We further tested whether neuromelanin-sensitive MRI was associated with the experience of subclinical paranoia as measured by the paranoia checklist. We found that there was no difference in neuromelanin-sensitive MRI signal between those with and without a first-degree relative. However, neuromelanin-sensitive MRI was significantly associated with the frequency subscore of the paranoia checklist, irrespective of familial risk (255 of 1879 voxels at p < 0.05, p

Identifiers

PMID41571699

DOI10.1038/s41537-026-00731-4

PMCPMC12929623

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.