Evidence map›Paper›PMID 41571695›Full record

ArticleNPJ Parkinson's disease2026

Pallidal beta power is associated with depression in Parkinson's disease.

Kara A Johnson, Patricia B Coutinho, Lauren E Kenney, Joshua K Wong, Justin D Hilliard, Kelly D Foote, Dawn Bowers, Gregory M Pontone, Coralie de Hemptinne

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kara A JohnsonNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA. kara.johnson@neurology.ufl.edu.
Patricia B CoutinhoNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Lauren E KenneyDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Joshua K WongNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Justin D HilliardNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Kelly D FooteNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Dawn BowersNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Gregory M PontoneNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Coralie de HemptinneNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.

Funding

Basal Ganglia Network Neurophysiology of Depression in Parkinson’s DiseaseK99NS137249 · NINDS · UNIVERSITY OF FLORIDA · PI JOHNSON, KARA ANN · 2025 to 2025
$112k
NIH HHS K99NS137249NINDS NIH HHS K99 NS137249
6 · The paper itself

Abstract

Depression is increasingly recognized as a prevalent source of disability in individuals with Parkinson's disease (PD), but its pathophysiology is not well understood. Neural activity in the basal ganglia, particularly the subthalamic nucleus, has been linked to depression in PD, but the role of the pallidum remains unclear. This retrospective study aimed to correlate preoperative depression symptoms with intraoperative resting-state neural activity recorded from the pallidum in N = 50 patients who underwent deep-brain stimulation (DBS) implantation surgery. Patients with clinically elevated depression symptoms exhibited elevated beta (13-30 Hz) power compared to patients without depression. Beta power, particularly high beta (20-30 Hz) power, was also associated with depression symptom severity, even when controlling for other demographic, clinical, pharmacological, and neurophysiological variables. These results suggest pallidal beta power as a potential biomarker of depression in PD and set the stage for tailoring DBS therapy to improve psychiatric symptoms in PD.

Identifiers

PMID41571695
PMCPMC12909943

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.