Evidence map›Paper›PMID 41571694›Full record

ArticleNature communications2026

Homotypic membrane-powered electrochemical microfluidic analysis of extracellular vesicles for precise cancer diagnosis.

Zihan Zou, Xi Jin, Xiaomeng Yu, Lijuan Li, Yi Pan, Guozhang Zhou, Zhaoyin Wang, Ya Cao, Jing Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zihan Zou *Center for Molecular Recognition and Biosensing, Shanghai Engineering Research Center of Organ Repair, Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), School of Life Sciences, Shanghai University, Shanghai, China.
Xi Jin *Key Laboratory of Breast Cancer, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Xiaomeng YuState Key Laboratory of Analytical Chemistry for Life Science, School of Life Sciences, Nanjing University, Nanjing, China.
Lijuan LiCenter for Molecular Recognition and Biosensing, Shanghai Engineering Research Center of Organ Repair, Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), School of Life Sciences, Shanghai University, Shanghai, China.
Yi PanCenter for Molecular Recognition and Biosensing, Shanghai Engineering Research Center of Organ Repair, Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), School of Life Sciences, Shanghai University, Shanghai, China.
Guozhang ZhouCenter for Molecular Recognition and Biosensing, Shanghai Engineering Research Center of Organ Repair, Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), School of Life Sciences, Shanghai University, Shanghai, China.
Zhaoyin WangJiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, China. zywang@njnu.edu.cn.
Ya CaoCenter for Molecular Recognition and Biosensing, Shanghai Engineering Research Center of Organ Repair, Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), School of Life Sciences, Shanghai University, Shanghai, China. conezimint@shu.edu.cn.
Jing ZhaoCenter for Molecular Recognition and Biosensing, Shanghai Engineering Research Center of Organ Repair, Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), School of Life Sciences, Shanghai University, Shanghai, China. jingzhao@t.shu.edu.cn.ORCID 0000-0001-6424-3085

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22176099National Natural Science Foundation of China (National Science Foundation of China) 82470534Natural Science Foundation of Shanghai
6 · The paper itself

Abstract

The cancer cell membrane, rich in tumor-associated antigens, effectively replicates the characteristics of cancer cells by presenting specific protein profiles. Leveraging the inherent binding capability of the cancer cell membrane, here we show a homotypic membrane-powered biomimetic interface for subtype-specific analysis of breast cancer extracellular vesicles (EVs). Specifically, the breast cancer cell membrane is employed to coat a gold substrate, thereby forming the biomimetic interface capable of selectively binding breast cancer EVs with similar subtype features. Subsequently, silver nanoparticles-tethered antibodies are adopted as electroactive immunoprobes to label these EVs, generating distinct electrochemical signals for quantitative analysis. Research findings demonstrate high selectivity and sensitivity of the interface for analyzing target EVs. Based on this, an electrochemical microfluidic device is developed and validated for its effectiveness in identifying subtype features of breast cancer patients. Therefore, our work provides a simple yet efficient platform for precise cancer diagnosis and personalized treatment.

Indexed as

Breast NeoplasmsCell MembraneElectrochemical TechniquesExtracellular VesiclesMicrofluidic Analytical TechniquesMicrofluidicsCell Line, TumorFemaleGoldHumansMetal NanoparticlesSilverGoldSilver

Identifiers

PMID41571694
PMCPMC12929599

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.