ArticleNature communications2026
Atypical pericapillary Ly6G⁺Nur77⁺ macrophages initiate type-2 immune responses to allergens in the mouse lung.
Audrey Meloun, Holly Bachus, Crystal Lewis, Brittany Dulek, Shivangi Dave, Dave Durell Hill, Gabriela Pessenda, Jose Carlos Gonzalez, P'ng Loke, Alexander F Rosenberg and 1 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Audrey MelounInnate Cells and Th2 Immunity Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-9433-1235 Holly BachusAdaptive Immunity and Immunoregulation Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Crystal LewisDepartment of Pathology-Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Brittany DulekCollaborative Bioinformatics Resource, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Shivangi DaveAdaptive Immunity and Immunoregulation Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Dave Durell HillDepartment of Biomedical Informatics and Data Science, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Gabriela PessendaType 2 Immunity Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Jose Carlos GonzalezDepartment of Neurobiology and McKnight Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0003-4612-1943 P'ng LokeType 2 Immunity Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-6211-3292 Alexander F RosenbergDepartment of Biomedical Informatics and Data Science, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Beatriz LeónInnate Cells and Th2 Immunity Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. beatriz.leonruiz@nih.gov.ORCID 0000-0002-3793-3854 Funding
U.S. Department of Health & Human Services | National Institutes of Health (NIH) 2R01AI116584
6 · The paper itselfAbstract
The mechanisms of airway allergen sensing and type 2 immune response initiation remain poorly understood. Using a mouse house dust mite (HDM)-induced allergic airway model, we identify a population of lung macrophages located close to alveolar capillaries that express Ly6G and the nuclear receptor Nr4a1/Nur77. These atypical Ly6G
Indexed as
AllergensAntigens, LyLungMacrophagesMacrophages, AlveolarTh2 CellsAnimalsAntigens, DermatophagoidesCell MovementDendritic CellsFemaleLeukotrienesLymph NodesMiceMice, Inbred C57BLPyroglyphidaeAllergensAntigens, DermatophagoidesAntigens, LyF2rl1 protein, mouseLeukotrienesReceptor, PAR-2
Identifiers
PMID41571657
PMCPMC12929616
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LicenceCC BY
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