Evidence map›Paper›PMID 41571640›Full record

ArticleNature communications2026

Camouflaged nanorobots target and regulate macrophage subcellular organelle crosstalk patterns to promote neural regeneration.

Qiangqiang Guo, Wei Wang, Xinzhao Jiang, Jincheng Tang, Feng Cai, Wenbo Wang, Lichen Zhang, Ziang Li, Yiyang Huang, Jie Wu and 9 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Transcriptomics Insights into Spinal Cord Injury for Therapy Development.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Qiangqiang Guo *Department of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China.
Wei Wang *Department of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China.
Xinzhao Jiang *Department of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China.
Jincheng Tang *Department of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China.ORCID 0000-0003-1652-3482
Feng CaiDepartment of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China.
Wenbo WangDepartment of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China.
Lichen ZhangDepartment of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China.
Ziang LiDepartment of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China.
Yiyang HuangDepartment of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China.
Jie WuDepartment of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China.
Liang ZhouDepartment of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China.
Haochen JiangDepartment of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China.
Yiwei ZhuDepartment of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China.
Guhao CaiDepartment of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China.
Ziyu LinDepartment of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China.
Yong GuDepartment of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China. guyongsuzhou@163.com.ORCID 0000-0002-0482-1610
Xuesong ZhuDepartment of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China. zhuxs@suda.edu.cn.ORCID 0000-0003-3579-2741
Liang ChenDepartment of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China. chenliang1972@sina.com.ORCID 0000-0001-8016-7596
Kun XiDepartment of Orthopedics, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, P.R. China. sudaxk@163.com.ORCID 0000-0002-0458-9866

Funding

Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University), Ministry of EducationNational Natural Science Foundation of ChinaNatural Science Foundation of Jiangsu ProvinceProject 333Soochow University Medical +X projectSuzhou Basic Research Pilot Program: Outstanding Young Scholars Lead ProjectSuzhou Gusu Health Talent Program
6 · The paper itself

Abstract

Macrophage (Mφ) phenotypic transformation is crucial in determining spinal cord injury (SCI) outcomes. However, the suborganelle crosstalk mechanisms-particularly between the endoplasmic reticulum (ER) and mitochondria-that mediate Mφ subgroup conversion during SCI remain underexplored. We aim to integrate niche intervention strategies and omics sequencing to investigate the effects of the metabolic crosstalk between ER stress (ERS) and mitochondria. Subsequently, we develop a dual-targeted camouflaged nanorobot (BP@D/N) that can reach the SCI site via systemic circulation and selectively interact with Mφ. We observe that Ero1α-mediated Ca

Indexed as

MacrophagesNerve RegenerationSpinal Cord InjuriesAnimalsAutonomous RobotsCalciumcGAS-STING Signaling PathwayDNA, MitochondrialEndoplasmic ReticulumHumansMiceMitochondriaNF-kappa BSignal TransductionCalciumDNA, MitochondrialNF-kappa B

Identifiers

PMID41571640
PMCPMC12929772

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.