Evidence map›Paper›PMID 41571628›Full record

ArticleBone research2026

PTH induced osteoblast Slit3 to decrease aberrant sensory innervation in degenerated vertebral endplates to relieve low back pain in mice.

Weixin Zhang, Arryn D Otte, Zhuolun Wang, Sisir Kumar Barik, Mei Wan, Xu Cao, Janet L Crane

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Weixin Zhang *Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Arryn D Otte *Division of Pediatric Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zhuolun WangDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sisir Kumar BarikDivision of Pediatric Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mei WanDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-9404-540X
Xu CaoDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Janet L CraneDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jcrane2@jhmi.edu.ORCID 0000-0001-7713-0936

Funding

Skeleton and Joint Degeneration with AgingP01AG066603 · NIA · JOHNS HOPKINS UNIVERSITY · PI CAO, XU · 2021 to 2025
$9.2M
NIA NIH HHS P01 AG066603U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) P01AG066603
6 · The paper itself

Abstract

During aging, the spine undergoes degenerative changes, particularly with vertebral endplate bone expansion and sclerosis, that are associated with nonspecific low back pain. We report that parathyroid hormone (PTH) treatment reduced vertebral endplate sclerosis and improved pain behaviors in three mouse models of spinal degeneration (aged, SM/J, and young lumbar spine instability mice). Aberrant innervation in the vertebral body and endplate during spinal degeneration was decreased with PTH treatment as quantified by PGP9.5

Indexed as

Low Back PainLumbar VertebraeMembrane ProteinsOsteoblastsParathyroid HormoneSensory Receptor CellsAnimalsDisease Models, AnimalMiceMembrane ProteinsParathyroid HormoneSlit3 protein, mouse

Identifiers

PMID41571628
PMCPMC12827982

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.