Evidence map›Paper›PMID 41571426›Full record

SynthesisBMJ open2026

Building a functional resonance analysis method (FRAM) in healthcare: a systematic review on how steps are reported, defined and supported by data.

Nienke Maria Luijcks, Tom Bazuin, Arie Adriaensen, Annelies Visser, Dave Dongelmans, Jop Groeneweg, Maarten J van der Laan, Perla Marang-van de Mheen

Abstract readSystematic Review
In one paragraph

Synthesis in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nienke Maria LuijcksDepartment of Safety and Security Science, Centre for Patient Safety, Delft University of Technology, Delft, the Netherlands n.m.luijcks@tudelft.nl.ORCID http://orcid.org/0009-0005-2404-4811
Tom BazuinDepartment of Surgery, University Medical Centre Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0009-0001-9134-9704
Arie AdriaensenDepartment of Multi Actor Systems, Delft University of Technology, Delft, the Netherlands.
Annelies VisserDepartment of Surgery, Amsterdam UMC Location AMC, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-7102-2627
Dave DongelmansDepartment of Intensive Care Medicine, Amsterdam University Medical Centre, Amsterdam, the Netherlands.
Jop GroenewegDepartment of Safety and Security Science, Centre for Patient Safety, Delft University of Technology, Delft, the Netherlands.
Maarten J van der LaanDepartment of Surgery, University Medical Centre Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-3125-1342
Perla Marang-van de MheenSafety and Security Science, Delft University of Technology Faculty of Technology Policy and Management, Delft, the Netherlands.ORCID http://orcid.org/0000-0003-1439-0989

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe functional resonance analysis method (FRAM) is increasingly used to analyse healthcare processes. FRAM uses four steps to analyse a process and its potential variability. We systematically reviewed studies using FRAM in healthcare on how the four steps in FRAM are reported, defined and supported by data.

designSystematic review following the preferred reporting items for systematic reviews and meta-analyses 2020 guidelines. DATA SOURCES: Web of Science, PubMed, Embase, Scopus, PsycINFO, Dimensions and Lens were searched up to December 2025. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: All peer-reviewed studies using FRAM in a healthcare context that presented a FRAM visualisation were included. The papers had to be written in English. DATA EXTRACTION AND SYNTHESIS: Two independent reviewers screened titles and abstracts, and subsequently the full text of selected papers. Data was extracted reporting on the steps of FRAM, how functions were supported by data, and the functions and couplings of the visualisations.

resultsSixty-eight papers were included, of which 20 (29%) reported at least one aspect of all four steps in FRAM. While most studies (85%) described how functions were supported by data, the methods used varied widely. Terminology was interpreted differently concerning variability, the output of variability and the effect of combined variability.

conclusionMost FRAM studies in healthcare do not report all steps of FRAM, and interpretations of key terms differ. FRAM studies should more clearly describe which steps of the method are conducted, and how data is collected and analysed. Refinement of FRAM guidelines, particularly on data use and terminology, would enhance consistency and comparability across studies. PROSPERO REGISTRATION NUMBER: CRD42024592858.

Indexed as

Delivery of Health CareResearch DesignHumansDelivery of Health Care, IntegratedHealth & safetyProtocols & guidelinesQuality Improvement

Identifiers

PMID41571426
PMCPMC12829402

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.