Evidence map›Paper›PMID 41571318›Full record

ArticleThe European respiratory journal2026

Physiological quotients and mortality: redefining lung function interpretation beyond FEV

Ben Knox-Brown, Lucy Robertson, Andre F S Amaral, Karl P Sylvester

Abstract read
In one paragraph

Article in The European respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Ben Knox-BrownCambridge University Hospitals NHS Foundation Trust, Cambridge, UK benjamin.knox-brown@nhs.net.ORCID https://orcid.org/0000-0001-5573-4413
Lucy RobertsonRoyal Papworth Hospital NHS Foundation Trust, Cambridge, UK.
Andre F S AmaralNational Heart and Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-0369-9449
Karl P SylvesterCambridge University Hospitals NHS Foundation Trust, Cambridge, UK.ORCID https://orcid.org/0000-0001-6851-1219

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundForced expiratory volume in 1 s quotient (FEV

methodsWe analysed data from adults referred for lung function testing at Cambridge University Hospital (CUH) and Royal Papworth Hospital (RPH) in the UK between 2016 and 2024. We investigated the stability of the 1st percentiles for FEV

resultsWe analysed data from 7717 CUH patients and 6054 RPH patients. At CUH, 51% were female compared with 45% at RPH. Mean±sd age was 57.9±14.9 years at CUH and 62.7±14.8 years at RPH. 1st percentile values were generally consistent across age groups but different for males and females for FEV

conclusionPhysiological quotients have greater discriminative ability in the prediction of all-cause mortality than existing metrics, providing an alternative standard for lung function interpretation.

Indexed as

LungRespiratory Function TestsAdultAgedCarbon MonoxideFemaleForced Expiratory VolumeHumansMaleMiddle AgedPulmonary Diffusing CapacityTotal Lung CapacityUnited KingdomVital CapacityCarbon Monoxide

Identifiers

PMID41571318
PMCPMC13347715

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.