Evidence map›Paper›PMID 41570150›Full record

ArticleScience (New York, N.Y.)2026

Couple-close: Unified approach to semisaturated cyclic scaffolds.

Jiaxin Xie, William Y Zhao, Johnny Z Wang, William L Lyon, Noriyuki Takanashi, Alice Long, Taylor M Sodano, Christopher B Kelly, Marian C Bryan, David W C MacMillan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Visible Light-Driven Copper-Catalyzed Asymmetric Synthesis via Sequential C(spAngewandte Chemie (International ed. in English) · 2026
    Article
  2. A General Photoredox Platform for the Hydroarylation of Olefins.Journal of the American Chemical Society · 2026
    Article
  3. Deaminative C(Journal of the American Chemical Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiaxin XieMerck Center for Catalysis at Princeton University, Princeton, NJ, USA.ORCID 0000-0002-5066-3553
William Y ZhaoMerck Center for Catalysis at Princeton University, Princeton, NJ, USA.ORCID 0009-0003-0060-7865
Johnny Z WangMerck Center for Catalysis at Princeton University, Princeton, NJ, USA.
William L LyonMerck Center for Catalysis at Princeton University, Princeton, NJ, USA.ORCID 0000-0002-7451-4755
Noriyuki TakanashiMerck Center for Catalysis at Princeton University, Princeton, NJ, USA.ORCID 0009-0009-2844-1231
Alice LongMerck Center for Catalysis at Princeton University, Princeton, NJ, USA.ORCID 0009-0002-3944-3565
Taylor M SodanoGlobal Discovery Chemistry, Johnson & Johnson Innovative Medicine, Spring House, PA, USA.ORCID 0000-0001-7040-0331
Christopher B KellyDiscovery Process Research, Johnson & Johnson Innovative Medicine, Spring House, PA, USA.ORCID 0000-0002-5530-8606
Marian C BryanGlobal Discovery Chemistry, Johnson & Johnson Innovative Medicine, Spring House, PA, USA.ORCID 0000-0002-3138-6888
David W C MacMillanMerck Center for Catalysis at Princeton University, Princeton, NJ, USA.ORCID 0000-0001-6447-0587

Funding

Photoredox Catalysis Applications in Organometallics and Chemical BiologyR35GM134897 · NIGMS · PRINCETON UNIVERSITY · PI David W MacMillan · 2020 to 2026
$6.3M
NIGMS NIH HHS R35 GM134897
6 · The paper itself

Abstract

Couple-close as a synthetic paradigm has the potential to change the way that synthetic organic chemists approach cyclic scaffold construction. One class of cyclic molecules that has been increasingly sought after is semisaturated cyclic scaffolds, whose specific blend of Csp

Identifiers

PMID41570150
PMCPMC12829907

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.