Evidence map›Paper›PMID 41570074›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

A surface-exposed cardiolipin synthase provides an unexpected paradigm for maintaining the Gram-negative outer membrane.

Carmen M Herrera, Lucas M Demey, Courtney K Ellison, M Stephen Trent

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Dark Side ofJournal of the American Chemical Society · 2026
    Article
  2. Lipid landscaping of the bacterial cell surface.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Carmen M HerreraDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.ORCID 0000-0002-8343-4837
Lucas M DemeyDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.
Courtney K EllisonDepartment of Microbiology, College of Art and Sciences, University of Georgia, Athens, GA 30602.ORCID 0000-0003-3259-079X
M Stephen TrentDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.ORCID 0000-0001-6134-1800

Funding

The Cell Envelope of the Multi-Drug Resistant Pathogen Acinetobacter baumanniiR01AI150098 · NIAID · UNIVERSITY OF GEORGIA · PI Michael Stephen Trent · 2020 to 2026
$3.9M
Synthesis and transport of outer membrane components across the Gram-negative cell envelopeR01AI176776 · NIAID · UNIVERSITY OF GEORGIA · PI Michael Stephen Trent · 2023 to 2026
$2.5M
The role of cardiolipin in the biogenesis of the Gram-negative bacterial cell envelopeR01AI174416 · NIAID · UNIVERSITY OF GEORGIA · PI Michael Stephen Trent · 2023 to 2026
$2.4M
Molecular mechanisms required for the maintenance of the gram-negative outer membraneR01AI138576 · NIAID · UNIVERSITY OF GEORGIA · PI TRENT, MICHAEL STEPHEN · 2018 to 2022
$2.0M
Molecular mechanisms of physical interactions between bacteria and their surroundingsR35GM150916 · NIGMS · UNIVERSITY OF GEORGIA · PI Courtney Kathleen Ellison · 2023 to 2026
$1.5M
DOD | USA | AFC | CCDC | ARO | Life Sciences Division, Army Research Office (Life Sciences Division ARO) W911NF2010195HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI138576HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI150098HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI176776HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM150916NIAID NIH HHS R01 AI138576NIAID NIH HHS R01 AI150098NIAID NIH HHS R01 AI174416NIAID NIH HHS R01 AI176776NIGMS NIH HHS R35 GM150916
6 · The paper itself

Abstract

Gram-negative bacteria have long been thought to confine primary glycerophospholipid synthesis to the inner membrane (IM). Here, we challenge this paradigm by identifying ClsO, an outer membrane (OM) lipoprotein from

Indexed as

Acinetobacter baumanniiBacterial Outer MembraneBacterial Outer Membrane ProteinsMembrane ProteinsTransferases (Other Substituted Phosphate Groups)CardiolipinsLipopolysaccharidesProteolipidsBacterial Outer Membrane ProteinsCardiolipinscardiolipin synthetaseLipopolysaccharidesMembrane ProteinsProteolipidsTransferases (Other Substituted Phosphate Groups)Acinetobactercardiolipinlipoproteinouter membranephospholipids

Identifiers

PMID41570074
PMCPMC12846801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.