ArticleJournal of neurosurgery. Case lessons2026
Primary dural lymphoma of the chronic lymphocytic lymphoma/small lymphocytic lymphoma-mimicking meningioma: illustrative case.
Article in Journal of neurosurgery. Case lessons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLymphomas originating from the dura mater of the skull, known as primary dural lymphomas (PDLs), are rare. Among these, cases of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) are exceptionally uncommon, and no standardized treatment protocols have been established. The authors report a rare case of CLL/SLL manifesting as PDL mimicking a skull base meningioma and review the relevant literature. OBSERVATIONS: A 71-year-old male presented with an extra-axial tumor extending from the petroclival to middle cranial fossa, which demonstrated progressive enlargement over the course of 1 year. The preoperative diagnosis was meningioma, and the patient subsequently underwent preoperative embolization followed by partial tumor resection. Histological examination revealed CLL/SLL. Postoperatively, the residual lesion was treated with radiation therapy, and no recurrence has been observed for > 3 years. LESSONS: CLL/SLL arising as PDL is difficult to distinguish from meningioma based on clinical and radiological findings. However, it generally shows favorable outcomes when treated with a combination of surgery and low-dose radiation therapy. https://thejns.org/doi/10.3171/CASE25831.
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