Evidence map›Paper›PMID 41569515›Full record

ReviewPsychiatric rehabilitation journal2026

The past and future of integrated biopsychosocial whole-health perspectives in psychiatric rehabilitation.

Rebecca Wolfe, Brianna Speakar, Mai Pham, Tierney Lorenz, William Spaulding

Abstract readReview
In one paragraph

Review in Psychiatric rehabilitation journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rebecca WolfeDepartment of Psychology, University of Nebraska-Lincoln.ORCID 0009-0000-9594-6306
Brianna SpeakarDepartment of Psychology, University of Nebraska-Lincoln.
Mai PhamDepartment of Psychiatry and Behavioral Sciences, University of Washington.
Tierney LorenzDepartment of Psychology, University of Nebraska-Lincoln.ORCID 0000-0002-4999-1584
William SpauldingDepartment of Psychology, University of Nebraska-Lincoln.ORCID 0000-0002-6271-4127

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GUDA, CHITTIBABU · 2016 to 2025
$42.8M
Testing the Efficacy of Ibudilast to Attenuate Meth-seeking and Associated Synaptic Inflammation at the Synapse (TEAMS)P20GM130461 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI KIMBERLY A TYLER · 2019 to 2026
$20.6M
Allostatic load, stress Response to Social Stress, frequency of Stress Exposure, and social Network structure/function (ARSEN)R01MD015905 · NIMHD · UNIVERSITY OF NEBRASKA LINCOLN · PI ANDREWS, ARTHUR · 2022 to 2025
$2.5M
Caroline Casey Feldtmose Charitable TrustNIGMS NIH HHS P20 GM130461NIGMS NIH HHS U54 GM115458NIH HHSNIMHD NIH HHS R01 MD015905Robert and Catherine Murray Charitable Trust
6 · The paper itself

Abstract

objectiveThis article describes the historical, contemporary, and probable future roles of biosystemic whole-health perspectives in the evolution of psychiatric rehabilitation.

methodsWe identify and discuss three examples of failures to fully consider the interaction of biological, psychological, and social levels of functioning, which have led to significant barriers to recovery: failure to account for physical morbidity in psychiatric disorders, lack of integration with modern understanding of inflammatory processes in psychiatric symptoms, and disregard for social and interpersonal factors.

resultsSignificant limitations in rehabilitation outcomes arise from failure to fully consider the molar (i.e., integrated) implications of molecular impairments and vulnerabilities, and vice versa. We articulate the consequences of molecular models of personal and social functioning as barriers to future research and clinical care and propose looking beyond the traditional scope of psychopathology and boundaries of mental health services to reach a whole-health understanding of psychiatric disorder and disability, rehabilitation, and recovery. CONCLUSIONS AND IMPLICATIONS FOR PRACTICE: The integrative biopsychosocial model is a particularly promising direction in the evolution of psychiatric rehabilitation, with strong clinical and theoretic implications that may guide much-needed change in policy and practice. Key to progress in our understanding of psychiatric disorder, disability, rehabilitation, and recovery is a perspective on science and clinical practice that values integration of multiple domains of knowledge as much as analytic dissection of molecular (i.e., unitary) processes. Reforms must be expected at all levels of health care service systems, in practitioner training, administration, and social policy. (PsycInfo Database Record (c) 2026 APA, all rights reserved).

Indexed as

Mental DisordersModels, BiopsychosocialPsychiatric RehabilitationHumans

Identifiers

PMID41569515
PMCPMC12829903

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.