Evidence map›Paper›PMID 41569503›Full record

ArticleJournal of autism and developmental disorders2026

Developmental Trajectories of Developmental Disorders: Early Diagnosis for an Early Intervention.

Veronica Sperandini, Federica Alice Maria Montanaro, Fabio Quarin, Cristina Caciolo, Stefania Falvo, Paolo Alfieri, Paola De Rose, Stefano Vicari

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Article in Journal of autism and developmental disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Veronica Sperandini *Bambino Gesù Children's Hospital, IRCCS, 00165, Rome, Italy.
Federica Alice Maria Montanaro *Bambino Gesù Children's Hospital, IRCCS, 00165, Rome, Italy.
Fabio QuarinBambino Gesù Children's Hospital, IRCCS, 00165, Rome, Italy.
Cristina CacioloBambino Gesù Children's Hospital, IRCCS, 00165, Rome, Italy.
Stefania FalvoBambino Gesù Children's Hospital, IRCCS, 00165, Rome, Italy.
Paolo AlfieriBambino Gesù Children's Hospital, IRCCS, 00165, Rome, Italy.
Paola De RoseBambino Gesù Children's Hospital, IRCCS, 00165, Rome, Italy. paola.derose@opbg.net.ORCID http://orcid.org/0000-0003-0715-2974
Stefano VicariBambino Gesù Children's Hospital, IRCCS, 00165, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEarly identification of children at risk for Intellectual Disability (ID) is complex, as formal diagnoses are often deferred until school age. However, early signs may emerge during the preschool years. This study aims to examine longitudinal changes in cognitive, adaptive and emotional-behavioral functioning from preschool to school age, to identify early markers predictive of later ID.

methodsEighty-eight children were assessed at two time points: preschool age (T0) and school age (T1). At T0, children were categorized into three diagnostic groups: Global Developmental Delay (GDD), Mixed Specific Developmental Disorder (MSDD), and Language Disorder (LD). At T1, the same children were re-evaluated and classified into: Intellectual Disability (ID), Language Disorder (LD), and Other Diagnoses (OD). Assessments included clinical observations, cognitive evaluations, and parent-reported questionnaires and interviews. Analyses were performed separately at T0, T1, and longitudinally.

resultsAt T0, all groups showed impaired adaptive functioning but differed in cognitive abilities, with the GDD group displaying more pronounced delays. At T1, only the ID group maintained significant deficits in both adaptive and cognitive domains. Regarding emotional-behavioral functioning, children with GDD exhibited more attention problems at T0. At T1, the ID group showed increased internalizing and externalizing symptoms, whereas LD and OD groups did not present significant psychopathological issues. A substantial rise in ID diagnoses was also observed at school age.

conclusionMonitoring developmental trajectories from an early age is essential to detect risk markers of ID. Early identification can support timely, targeted interventions for children and their families, improving long-term outcomes.

Indexed as

Adaptive functioningGlobal developmental disordersIntellectual disabilityNeurodevelopmental disordersPsychopathology

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.