Evidence map›Paper›PMID 41569434›Full record

ArticleVeterinary research communications2026

Antioxidant protection by vanillin aldehyde against chronic pymetrozine-induced hepatic, renal, and DNA damage in African catfish.

Afaf N Abdel Rahman, Mohamed Fouad Mansour, Abdallah Tageldein Mansour, Hesham A Hassanien, Ahmed Abbas, Mohamed Ashour, Roshmon Thomas Mathew, Sara T Elazab, Eman Wagih, Rowida E Ibrahim

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Article in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Afaf N Abdel RahmanDepartment of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, PO Box 44511, Zagazig, Egypt. afne56@gmail.com.
Mohamed Fouad MansourDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Zagazig University, PO Box 44511, Zagazig, Egypt.
Abdallah Tageldein MansourAnimal and Fish Production Department, College of Agricultural and Food Sciences, King Faisal University, PO Box 420, Al- Hasa, Hofuf, 31982, Saudi Arabia. amansour@kfu.edu.sa.
Hesham A HassanienAnimal and Fish Production Department, College of Agricultural and Food Sciences, King Faisal University, PO Box 420, Al- Hasa, Hofuf, 31982, Saudi Arabia.
Ahmed AbbasAnimal and Fish Production Department, College of Agricultural and Food Sciences, King Faisal University, PO Box 420, Al- Hasa, Hofuf, 31982, Saudi Arabia.
Mohamed AshourFish Resources Research Center, King Faisal University, PO Box 420, Hofuf, Al-Ahsa, 31982, Saudi Arabia.
Roshmon Thomas MathewFish Resources Research Center, King Faisal University, PO Box 420, Hofuf, Al-Ahsa, 31982, Saudi Arabia.
Sara T ElazabDepartment of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.
Eman WagihDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, PO Box 44511, Zagazig, Sharkia, Egypt.
Rowida E IbrahimDepartment of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, PO Box 44511, Zagazig, Egypt.

Funding

Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University KFU253386
6 · The paper itself

Abstract

Worldwide, aquatic ecosystems are increasingly threatened by the inappropriate overuse of insecticides, posing risks to aquatic life. There is a need for alternatives that are safe, economical, and environmentally friendly. Thus, the protective effects of dietary vanillin (VAN) against the detrimental consequences of long-term pymetrozine (PMZ) exposure in Clarias gariepinus (African catfish) are investigated in this study. To address this, fish were randomly assigned into four groups: control, VAN (10 mg/kg diet), PMZ (0.065 mg/L), and VAN + PMZ for two months, with 40 fish in each group. Chronic PMZ exposure significantly elevated the concentrations of alanine aminotransferase, aspartate aminotransferase, creatinine, glucose, cortisol, malondialdehyde, and 8-hydroxy-2’-deoxyguanosine by 131.44, 134.55, 564.28, 49.65, 76.00, 174.69, and 281.97%, respectively (P < 0.001), compared with the control. Conversely, total protein, albumin, globulin, total antioxidant capacity, and catalase activity decreased by 27.76, 32.73, 21.74, 58.20, and 60.41%, respectively (P < 0.001). Histological examination revealed that PMZ provoked a range of histopathological changes in the vital organs (liver, kidney, gills, and brain), including vacuolation, hydropic degeneration, and necrosis. Remarkably, VAN supplementation in the PMZ-exposed group significantly ameliorated these effects, reducing alanine aminotransferase (40.80%), aspartate aminotransferase (33.04%), creatinine (35.48%), glucose (22.70%), cortisol (18.39%), malondialdehyde (39.62%), and 8-hydroxy-2’-deoxyguanosine (26.18%) (P < 0.001). Moreover, it increased total protein, albumin, globulin, total antioxidant capacity, and catalase activity by 25.85, 34.67, 16.67, 404.08, and 364.86%, respectively (P < 0.001). Histological analyses of the VAN + PMZ group showed largely normal tissue architecture, with only mild hepatic cell degeneration, a few necrotic renal tubules, slight gill filament erosion, and occasional degenerated neurons. Dietary VAN also significantly reduced mortality from 37.50% (95% confidence interval: 24.20–53.00%) in the PMZ group to 12.50% (95% confidence interval: 5.50–26.10%) in the VAN + PMZ group (P = 0.018, Fisher’s exact test). In conclusion, dietary VAN demonstrates considerable potential in mitigating the adverse effects of PMZ on C. gariepinus. However, further field-based studies are warranted before recommending its application in aquaculture practice.

Indexed as

AntioxidantsBenzaldehydesCatfishesDNA DamageFish DiseasesInsecticidesTriazinesAnimalsDietKidneyLiverWater Pollutants, ChemicalAntioxidantsBenzaldehydesInsecticidesTriazinesvanillinWater Pollutants, ChemicalAquacultureClarias gariepinusInnovation in dietNovel pyridine azomethine insecticidePhenolic aldehydePhysiological status

Identifiers

PMID41569434

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.