Evidence map›Paper›PMID 41569390›Full record

ArticleJournal of assisted reproduction and genetics2026

Joint effects of IVF and cancer history on birth outcomes.

Abby L Chen, Shufeng Li, Valerie L Baker, Philip J Lupo, Hazel B Nichols, Michael L Eisenberg, Barbara Luke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abby L ChenDepartment of Urology, Stanford University School of Medicine, 1000 Welch Rd Ste 100, MC 5756, Palo Alto, Stanford, CA, 94305, USA. achen95@stanford.edu.ORCID http://orcid.org/0000-0002-4985-2787
Shufeng LiDepartment of Urology, Stanford University School of Medicine, 1000 Welch Rd Ste 100, MC 5756, Palo Alto, Stanford, CA, 94305, USA.
Valerie L BakerDepartment of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.ORCID http://orcid.org/0000-0003-1762-7339
Philip J LupoDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322, USA.ORCID http://orcid.org/0000-0003-0978-5863
Hazel B NicholsDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, 27599, USA.ORCID http://orcid.org/0000-0003-0972-1560
Michael L EisenbergDepartment of Urology, Stanford University School of Medicine, 1000 Welch Rd Ste 100, MC 5756, Palo Alto, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0001-5482-0141
Barbara LukeDepartment of Obstetrics, Gynecology and Reproductive Biology, Michigan State University College of Human Medicine, East Lansing, MI, 48824, USA.ORCID http://orcid.org/0000-0002-0405-8133

Funding

A US-UK Collaborative Study of the Health of Children Born From In Vitro Fertilization: From Conception Through Young AdulthoodR01HD112081 · NICHD · EMORY UNIVERSITY · PI BARBARA JOAN LUKE, Philip Lupo · 2023 to 2026
$2.3M
NIH HHS R01 HD112081
6 · The paper itself

Abstract

purposeTo examine how live birth rates, preterm birth, and major birth defects are affected by parental cancer history and conception method.

methodsIVF births were identified by linking the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System to birth certificates in three States. For each IVF-conceived birth, the subsequent 10 naturally conceived births (from birth certificates) created the comparison group. Parental cancer history was identified by linkage to state cancer registries. Preterm birth (PTB) was defined from birth certificates; birth defects (BD) from state BD registries. Adjusted odds ratios (aOR) and 95% confidence intervals (CI) for PTB and BDs were calculated with logistic regression.

resultsOverall, 30.5% of female cancer survivors who underwent IVF had a live birth. Of 814,658 total births, 9.1% were PT and 4.4% had BDs. IVF was associated with increased risk of PTB and major BDs regardless of parental cancer history. Maternal, but not paternal, cancer history was associated with an increased risk of PTB. No increase in BDs was observed with parental cancer history alone. Risks of both PTB and BDs were highest among multiple births.

conclusionsIVF use was associated with increased risk of PTB and major BDs. Parental cancer history did not elevate the risk of BDs, which remains low. Based on these data, cancer survivors attempting to conceive with or without IVF can be counseled that the magnitude of risk for PTB and major BD was similar for cancer survivors compared with those who conceive without a parental cancer history.

Indexed as

Congenital AbnormalitiesFertilization in VitroNeoplasmsPremature BirthAdultBirth RateFemaleHumansInfant, NewbornLive BirthMalePregnancyPregnancy OutcomeRegistriesAssisted reproductionCancerEpidemiologyInfertilityIVF/ICSI outcome

Identifiers

PMID41569390
PMCPMC12982715

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.