Evidence map›Paper›PMID 41569217›Full record

ArticleJACC. Asia2026

Profiles of Comprehensive Morphological Phenotypes and Outcomes in Functional Mitral Regurgitation.

Cheng-Wei Lien, Wei-Jyun Wang, Kuan-Yu Lai, Jih-Chang Yu, Chung-Yen Lee, Jui Wang, Meng-Han Tsai, Chung-Lieh Hung, Shih-Hsien Sung, Hsien-Li Kao and 3 more

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Article in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cheng-Wei LienDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan.
Wei-Jyun WangDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Kuan-Yu LaiDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Jih-Chang YuDepartment of Statistics, National Taipei University, Taipei, Taiwan.
Chung-Yen LeeDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Jui WangInstitute of Epidemiology and Prevention Medicine, National Taiwan University, Taipei, Taiwan; Health Data Research Center, National Taiwan University, Taipei, Taiwan.
Meng-Han TsaiDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chung-Lieh HungCardiovascular Division, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan.
Shih-Hsien SungDivision of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Hsien-Li KaoDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Yi-Lwun HoDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Telehealth Center, National Taiwan University Hospital, Taipei, Taiwan.
Masaaki TakeuchiDepartment of Laboratory and Transfusion Medicine, Hospital of University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
Li-Tan YangDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Telehealth Center, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: litannyang@yahoo.com.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrent guidelines do not include phenotypical classifications in functional mitral regurgitation (FMR).

objectivesThe study sought to classify FMR into 3 morphological phenotypes and assess determinants of mortality.

methodsWe included patients with ≥moderately severe FMR from 2 tertiary centers. FMR was classified as ventricular functional mitral regurgitation with symmetrical tethering (VFMRst), ventricular functional mitral regurgitation with asymmetrical tethering (VFMRat), or atrial functional mitral regurgitation (AFMR). The primary composite endpoint was cardiovascular death and death equivalent (ie, left ventricular assist device implantation or heart transplantation).

resultsOf 699 patients (70 years [Q1-Q3: 60-79 years], 46% female), VFMRst was the most prevalent (54%). VFMRat exhibited larger mitral regurgitation vena contracta (7.7 mm [Q1-Q3: 7-8.7 mm] vs 7.3 mm [Q1-Q3: 6.7-8.2 mm]) but smaller left ventricular end-diastolic volume index (100 mL/m

conclusionsVFMRat exhibited more disproportionate features than VFMRst. AFMR with hamstrung posterior MV may indicate a more advanced disease stage. Morphological phenotypes alone were not associated with adjusted outcomes. LASr, A4C-LVLS, and DBP may assist in risk stratification in FMR.

Indexed as

functional mitral regurgitationheart failuretransthoracic echocardiography

Identifiers

PMID41569217
PMCPMC13080753

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