ArticleThe Journal of cell biology2026
Anaphase onset requires CKS-1-mediated destruction of securin in meiosis I and cyclin B1 in meiosis II.
Article in The Journal of cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The Small but Versatile Cyclin-Dependent Kinase Subunit CKS: C. elegans CKS-1 Regulates Anaphase Onset and Is Required for Anaphase B During Oocyte Meiosis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Outer kinetochore proteins form linear elements to regulate vesicle transport.Journal of cell science · 2026Article
- CKS-1 and the choreography of meiotic chromosome segregation.The Journal of cell biology · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
The cyclin-dependent kinase subunit CKS remains poorly understood. We found that Caenorhabditis elegans CKS-1 and its partner CDK-1 co-localized to the cytosol, chromosomes, and spindle structures throughout cell division. Nevertheless, CKS-1 was required well after CDK-1, during oocyte meiosis I metaphase, which was prolonged in cks-1 mutants. Anaphase A precedes anaphase B in C. elegans oocytes, and while delayed in onset, chromosomes in cks-1 mutants separated normally during meiosis I anaphase A but failed to separate further and instead rapidly transitioned into meiosis II prometaphase, skipping anaphase B. The anaphase A to B transition also was defective during meiosis II. Furthermore, meiosis I anaphase B required that CKS-1 be bound to CDK-1 and have a functional anion pocket. Finally, our results suggest that CKS-1 promotes anaphase onset during meiosis I through securin destruction and during meiosis II through cyclin B1 destruction, and that both securin and cyclin B3 have positive roles independent of their destruction during meiosis II.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.