Evidence map›Paper›PMID 41569083›Full record

ArticleeLife2026

A titin missense variant drives atrial electrical remodeling and is associated with atrial fibrillation.

Mahmud Arif Pavel, Hanna Chen, Michael Hill, Arvind Sridhar, Miles Barney, Jaime DeSantiago, Abhinaya Baskaran, Asia Owais, Shashank Sandu, Faisal A Darbar and 5 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Spectrum and Clinical Interpretation ofInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Mahmud Arif Pavel *Division of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, United States.ORCID https://orcid.org/0009-0005-2813-315X
Hanna Chen *Division of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, United States.
Michael Hill *Division of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, United States.ORCID https://orcid.org/0000-0002-5973-0804
Arvind SridharDivision of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, United States.
Miles BarneyDivision of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, United States.
Jaime DeSantiagoDivision of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, United States.
Abhinaya BaskaranDivision of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, United States.
Asia OwaisDivision of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, United States.
Shashank SanduDivision of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, United States.
Faisal A DarbarDivision of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, United States.
Aylin Ornelas LoredoDivision of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, United States.
Bahaa Al-AzzamDivision of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, United States.
Brandon ChalazanDivision of Genetics, Genomics, and Metabolism, Department of Pediatrics, Lurie Children's Hospital of Chicago, Chicago, United States.
Jalees RehmanDivision of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, United States.ORCID https://orcid.org/0000-0002-2787-9292
Dawood DarbarDivision of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, United States.ORCID https://orcid.org/0000-0002-4103-5977

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Genotype-guided therapy for atrial fibrillationR01HL148444 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DARBAR, DAWOOD · 2020 to 2024
$3.5M
Human iPSC-derived atrial cardiomyocytes to model atrial fibrillation in a dishR01HL150586 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DARBAR, DAWOOD, KHETANI, SALMAN R · 2020 to 2023
$2.6M
Training Program in Personalized Cardiovascular Medicine (TPIPCVM)T32HL139439 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DARBAR, DAWOOD · 2018 to 2022
$2.1M
Short-Term Research Training Program in NIDDK Mission AreasT35DK131960 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Waddah A. Alrefai, JAMES P. LASH · 2022 to 2026
$400k
American Heart Association 23POST1019044NCATS NIH HHS UL1 TR002003NHLBI NIH HHS R01 HL148444NHLBI NIH HHS R01 HL150586NHLBI NIH HHS T32 HL139439NIDDK NIH HHS T35 DK131960NIH HHS R01 HL148444NIH HHS R01 HL150586NIH HHS T32 HL139439
6 · The paper itself

Abstract

Rare and common genetic variants contribute to the risk of atrial fibrillation (AF). Although ion channels were among the first AF candidate genes identified, rare loss-of-function variants in structural genes, such as

Indexed as

Atrial FibrillationAtrial RemodelingConnectinMutation, MissenseHeart AtriaHumansInduced Pluripotent Stem CellsMyocytes, CardiacConnectinTTN protein, humanHiPSC-aCMsHiPSC-derived atrial cardiomyocyteshumaninduced stem cellsiPSCmedicineregenerative medicinestem cells

Identifiers

PMID41569083
PMCPMC12826672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.