Evidence map›Paper›PMID 41569044›Full record

ArticleMicrobiology spectrum2026

Siddhi Chitre, Raad Z Gharaibeh, Rachel C Newsome, Jinmai Jiang, Andrew Brock, Thomas D Schmittgen, Christian Jobin

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siddhi ChitreDepartment of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.ORCID 0000-0003-2139-3125
Raad Z GharaibehDepartment of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.ORCID 0000-0001-5484-8902
Rachel C NewsomeDepartment of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.ORCID 0000-0003-4124-8339
Jinmai JiangDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-2418-6781
Andrew BrockDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-8312-1809
Thomas D Schmittgen *Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-2812-8546
Christian Jobin *Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.ORCID 0000-0002-3733-1001

Funding

Training Program for Applied Research and Development in Genomic MedicineT32HG008958 · NHGRI · UNIVERSITY OF FLORIDA · PI Larisa Humma Cavallari, Stephen E. Kimmel · 2018 to 2026
$3.8M
NHGRI NIH HHS T32 HG008958
6 · The paper itself

Abstract

The intestinal microbiota has been shown to influence host-derived microRNAs (miRNAs), small regulatory RNAs involved in host-pathogen interactions. However, the specific role of individual bacterial species in modulating host extracellular vesicles (EV)-derived miRNA profiles remains unclear. We compared stool miRNA profiles from three groups: (i) Germ-free (GF) mice, (ii) mice colonized with a consortium of 13 bacteria (C13), and (iii) mice colonized with C13 and IMPORTANCE: Host-derived microRNAs (miRNAs) are known to regulate bacterial gene expression and maintain gut homeostasis. However, how these miRNAs survive harsh gut conditions to remain functional is not fully understood. This study tested whether extracellular vesicles (EV) carry microRNAs in the gut and whether infection with the enteric pathogen

Indexed as

Campylobacter InfectionsCampylobacter jejuniHost-Pathogen InteractionsMicroRNAsAnimalsColonExtracellular VesiclesFecesFemaleGastrointestinal MicrobiomeGerm-Free LifeMiceVirulenceMicroRNAsbacterial consortiumcolibactincytolethal distending toxininflammationmicrobiomemiRNAvirulence

Identifiers

PMID41569044
PMCPMC12955423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.