ArticleScience progress
Activation of TRPV4 to drive pyroptosis-dependent orthodontic tooth remodeling.
Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The 'Roller Coaster Effect' in Clear Aligner Premolar Extraction Cases: Posterior Open Bite and Cephalometric Risk Factors.Orthodontics & craniofacial research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveOrthodontic tooth movement (OTM) relies on mechanotransduction and inflammatory responses within the periodontal ligament (PDL). This study aimed to elucidate the role of transient receptor potential vanilloid 4 (TRPV4) in mediating mechanical force-induced pyroptosis in human PDL (hPDL) cells and its functional impact on osteoclast activation during OTM.MethodshPDL cells were isolated from premolars extracted for orthodontic reasons and characterized for stem cell properties (CD73+/CD90+/CD105+; CD34-/CD45-). An in vitro OTM model was established by applying compressive force (0-2.0 g/cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.