Evidence map›Paper›PMID 41568981›Full record

ArticleJournal of virology2026

Rift Valley fever virus activates multiple cell death pathways in neurons.

Kaleigh A Connors, Zachary D Frey, Matthew J Demers, Morgan Midgett, Connor Williams, Douglas S Reed, Zachary P Wills, Amy L Hartman

Abstract read
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaleigh A ConnorsDepartment of Infectious Disease and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Zachary D FreyCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Matthew J DemersCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Morgan MidgettCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Connor WilliamsCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Douglas S ReedCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-0076-9023
Zachary P WillsDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Amy L HartmanDepartment of Infectious Disease and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-0857-2973

Funding

Practices CoreUC7AI180311 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI William Paul Duprex · 2023 to 2026
$13.2M
Characterizing the role of LDL related receptor 1 (Lrp1) as host entry factor for multiple bunyavirusesR01AI169850 · NIAID · WASHINGTON UNIVERSITY · PI Gaya K. Amarasinghe, Amy L Hartman · 2023 to 2026
$3.1M
Mechanisms of Neuronal Infection by Prototype Emerging BunyavirusesR01AI178378 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Amy L Hartman · 2023 to 2026
$3.0M
Neuroprotective anti-inflammatory drugs as a novel combination therapy for neurological Rift Valley FeverR01NS101100 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARTMAN, AMY L · 2017 to 2021
$1.7M
Comparative Analysis of Bunyavirus NeuropathogenesisR56AI171920 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARTMAN, AMY L · 2022 to 2022
$1.1M
NIAID NIH HHS R01 AI169850NIAID NIH HHS R01 AI178378NIAID NIH HHS R56 AI171920NIAID NIH HHS UC7 AI180311NINDS NIH HHS R01 NS101100
6 · The paper itself

Abstract

Neuronal injury and death contribute to long-term impairments and lethality during viral encephalitis. Rift Valley fever virus (RVFV), an arbovirus with epidemic potential, can manifest as late-onset encephalitis in humans, yet this disease outcome remains understudied. A lethal rodent model of RVF encephalitis is characterized by a dysregulated immune response, neuronal necrosis, and blood-brain barrier breakdown that precedes lethality. In this study, we built upon this prior work using both

Indexed as

Cell DeathEncephalitis, ViralNeuronsRift Valley FeverRift Valley fever virusAnimalsApoptosisBrainCells, CulturedDisease Models, AnimalMiceNecroptosisPyroptosisbunyaviruscell deathneuronPANoptosisPhenuiviridaeRift Valley feverviral encephalitis

Identifiers

PMID41568981
PMCPMC12911891

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.