Evidence map›Paper›PMID 41568970›Full record

ArticleAntimicrobial agents and chemotherapy2026

Novel metabolic adaptation driven by glycoside hydrolase family 25 protein contributes to increasing trimethoprim-sulfamethoxazole resistance in clinical human

Xiaowen Yang, Wenqing Ning, Yaqin Yuan, Xuexin Hou, Shengxin Ge, Hai Jiang, Xiaowei Peng, Tianqi Xue, Hongyan Zhao, Biao Kan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaowen Yang *Key Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, People's Republic of China.ORCID 0000-0002-1909-9085
Wenqing Ning *Key Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, People's Republic of China.
Yaqin Yuan *Key Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, People's Republic of China.
Xuexin HouNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
Shengxin GeKey Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, People's Republic of China.
Hai JiangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
Xiaowei PengNational Reference Laboratory for Animal Brucellosis, China Institute of Veterinary Drug Control, Beijing, People's Republic of China.
Tianqi XueKey Laboratory of Jiangsu Preventive Veterinary Medicine, Key Laboratory of Avian Preventive Medicine, Ministry of Education, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, People's Republic of China.
Hongyan ZhaoNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
Biao KanNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.ORCID 0000-0002-6141-4552
Jiabo DingKey Laboratory of Animal Biosafety Risk Prevention and Control (North), Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, People's Republic of China.ORCID 0000-0002-8515-9031

Funding

Agricultural Science and Technology Innovation Program ASTIP-IAS-15Beijing Municipal Natural Science Foundation 7222120Central Public-Interest Scientific Institution Basal Research Fund Y2025YC047Innovation Program of Chinese Academy of Agricultural Sciences CAAS-CSLPDCP-202403National Natural Science Foundation of China 81902105
6 · The paper itself

Abstract

Brucellosis, caused by

Indexed as

Anti-Bacterial AgentsBrucella melitensisTrimethoprim, Sulfamethoxazole Drug CombinationBacterial ProteinsBrucellosisChinaDrug Resistance, BacterialDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsPolymorphism, Single NucleotideAnti-Bacterial AgentsBacterial ProteinsTrimethoprim, Sulfamethoxazole Drug CombinationBrucellaglycoside hydrolase family 25 proteinmetabolic adaptationstrimethoprim-sulfamethoxazole resistancewgSNPs

Identifiers

PMID41568970
PMCPMC12959145

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.