Evidence map›Paper›PMID 41568952›Full record

ArticleMicrobiology spectrum2026

Rising incidence of carbapenem-resistant

Helena Tsakmaklis, Niklas M Weidner, Kaan Kocer, Rouven Behnisch, Dirk Jäger, Patrick Michl, Markus Mieth, Elena Busch, Christian Brandt, Alexander H Dalpke and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Helena Tsakmaklis *Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.
Niklas M Weidner *Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.
Kaan KocerInstitute of Medical Microbiology, University Hospital Schleswig-Holstein Campus Lübeck and University of Lübeck, Lübeck, Germany.
Rouven BehnischInstitute of Medical Biometry (IMBI), Heidelberg University, Heidelberg, Germany.
Dirk JägerNational Center for Tumor Diseases, Heidelberg University, Medical Faculty Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.
Patrick MichlDepartment of Gastroenterology, Hepatology and Infectious Diseases, Heidelberg University, Medical Faculty Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.
Markus MiethDepartment of General, Visceral and Transplant Surgery, Heidelberg University, Medical Faculty Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.
Elena BuschDepartment of Hematology, Oncology and Rheumatology, Heidelberg University, Medical Faculty Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.
Christian BrandtDepartment of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.
Alexander H DalpkeDepartment of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.
Dennis NurjadiInstitute of Medical Microbiology, University Hospital Schleswig-Holstein Campus Lübeck and University of Lübeck, Lübeck, Germany.
Sebastien BoutinInstitute of Medical Microbiology, University Hospital Schleswig-Holstein Campus Lübeck and University of Lübeck, Lübeck, Germany.
Isabel SpäthDepartment of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany.ORCID 0009-0006-9054-3675

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, a threatening rise in carbapenem-resistant IMPORTANCE: In this study, we analyzed the significant increase in CRC strains at our tertiary-care hospital over the past six years. Our findings revealed that, unlike classical outbreak scenarios - typically characterized by the clonal expansion of one strain within a single ward or unit - the rising incidence of CRC was driven by the dissemination of numerous genetically diverse strains across multiple departments. The hospital sewage system was identified as a reservoir and plays an important role in the rapid proliferation and dissemination of CRC. The high complexity of the situation presents a new challenge, as transmission pathways are now difficult to trace, hindering effective prevention. Remarkably, the majority of patients affected by CRC were merely colonized, and severe infections were not observed. It remains to be determined whether this pattern reflects a site-specific phenomenon or indicates a broader trend on a European or even global scale.

Indexed as

Carbapenem-Resistant EnterobacteriaceaeCarbapenemsCitrobacterEnterobacteriaceae InfectionsWastewaterAnti-Bacterial Agentsbeta-LactamasesGermanyHumansIncidenceMicrobial Sensitivity TestsMultilocus Sequence TypingRetrospective StudiesTertiary Care CentersWhole Genome SequencingAnti-Bacterial Agentsbeta-LactamasesCarbapenemsWastewatercarbapenem-resistant EnterobacteralesCitrobacter spp.hospital wastewater systemincidence rate

Identifiers

PMID41568952
PMCPMC12955474

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.