Evidence map›Paper›PMID 41568949›Full record

ArticleMicrobiology spectrum2026

A combined genetic and chemical approach for identifying novel antifungal compounds against

Soobin Shin, Hyeon Ji Je, Yugyeong Choi, Bomin Kim, Jisu Hong, Juwon Yang, Jae Woo Han, Joon-Ho Lee, Hyun Suk Yeom, Gyung Ja Choi and 2 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Soobin Shin *Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.ORCID 0000-0001-5813-5504
Hyeon Ji Je *Center for Eco-friendly New Materials, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Yugyeong ChoiCenter for Eco-friendly New Materials, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Bomin KimCenter for Eco-friendly New Materials, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Jisu HongCenter for Eco-friendly New Materials, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Juwon YangDepartment of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.
Jae Woo HanCenter for Eco-friendly New Materials, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Joon-Ho LeeInfectious Diseases Therapeutics Research Center, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Hyun Suk YeomCenter for Eco-friendly New Materials, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Gyung Ja ChoiCenter for Eco-friendly New Materials, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Hokyoung SonDepartment of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.ORCID 0000-0001-5080-7951
Hun KimCenter for Eco-friendly New Materials, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.ORCID 0000-0001-6727-4469

Funding

Korea Research Institute of Chemical Technology KK2632-20Rural Development Administration RS-2024-00397586
6 · The paper itself

Abstract

Chemical fungicides act by targeting specific proteins or pathways, known as modes of action (MoAs). In this study, we established a systematic screening platform using IMPORTANCE: This study provides a perspective on developing strategies to manage fungal pathogens with implications for agriculture and food security. The effectiveness of current fungicides is increasingly limited by resistance, narrow target ranges, and environmental concerns. By combining genetic approaches with chemical screening, this work offers a more systematic way to identify candidate antifungal agents and better understand their possible mechanisms. The framework may also be adapted for use in other areas, including medical and veterinary applications, suggesting potential broader applicability. In addition, the emphasis on exploring new molecular scaffolds supports efforts to develop more sustainable and long-term disease management strategies. Overall, this study contributes useful knowledge and tools for advancing antifungal research and improving approaches to pathogen control.

Indexed as

Antifungal AgentsFungicides, IndustrialFusariumDrug DiscoveryGene Knockout TechniquesMicrobial Sensitivity TestsSmall Molecule LibrariesAntifungal AgentsFungicides, IndustrialSmall Molecule Librariesantifungal discoveryfungicide targetFusarium graminearumkinase inhibitor

Identifiers

PMID41568949
PMCPMC12955473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.