Evidence map›Paper›PMID 41568883›Full record

ArticleSICOT-J2026

What's new on giant cell tumor of bone.

Shinji Tsukamoto, Costantino Errani, Tessa Balach, Tomas Zamora, Eduardo Ortiz-Cruz, Raja Bhaskara Rajasekaran, Raymond Yau, Tao Ji, Israel Pérez-Muñoz, Francisco Linares and 4 more

Abstract read
In one paragraph

Article in SICOT-J, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shinji TsukamotoDepartment of Orthopaedic Surgery, Nara Medical University, 840, Shijo-cho, Kashihara-City, 634-8521, Nara, Japan.ORCID 0000-0002-8419-2008
Costantino ErraniDepartment of Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136, Bologna, Italy.ORCID 0000-0002-4504-2867
Tessa BalachDepartment of Orthopaedic Surgery, University of Chicago, 5758 S. Maryland Avenue, Chicago 60637, Illinois, USA.ORCID 0000-0002-7909-7292
Tomas ZamoraDepartment of Orthopaedic Surgery, Pontificia Universidad Catolica de Chile, Diagonal Paraguay 362, 8330077 Santiago, Chile.ORCID 0000-0003-3791-0449
Eduardo Ortiz-CruzOrthopaedic Surgery and Traumatology Department, La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain.
Raja Bhaskara RajasekaranDepartment of Musculoskeletal Oncology, Ganga Medical Centre & Hospitals Pvt Ltv, 313, Mettupalayam Rd, Saibaba Koil, Coimbatore 641043, Tamil Nadu, India.ORCID 0000-0003-0378-7411
Raymond YauDepartment of Orthopaedics & Traumatology, The University of Hong Kong, 21 Sassoon Rd, Pok Fu Lam, Hong Kong, PR China.ORCID 0000-0002-5508-4622
Tao JiDepartment of Musculoskeletal Tumor, People's Hospital, Peking University, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, PR China.
Israel Pérez-MuñozOrthopedics and Orthopedic Surgery Department, Ramon y Cajal University Hospital, M-607, Km. 9, 100, Fuencarral-El Pardo, 28034, Madrid, Spain.
Francisco LinaresDepartamento de Ortopedia, Pontificia Universidad Javeriana, Carrera 7 No. 40-62, 110231, Bogotá, Colombia.
Andrea AngeliniDepartment of Orthopedics and Orthopedic Oncology, University of Padova, Via Giustiniani 3, 35128, Padua, Italy.ORCID 0000-0002-8823-448X
Pietro RuggieriDepartment of Orthopedics and Orthopedic Oncology, University of Padova, Via Giustiniani 3, 35128, Padua, Italy.ORCID 0000-0001-9617-9882
Joseph BeneveniaDepartment of Orthopaedics, Rutgers New Jersey Medical School, Medical Science Building, 185 South Orange Avenue, Newark, 07103, New Jersey, USA.
Andreas F MavrogenisFirst Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, 41 Ventouri Street, 15562 Holargos, Athens, Greece.ORCID 0000-0003-0807-0719

Funding

None
6 · The paper itself

Abstract

When treating extremities affected by giant cell tumor of bone (GCTB), curettage should be performed to preserve the joint as much as possible in order to obtain a good functional outcome. The local recurrence risk is high following curettage, but new techniques are being developed to reduce local recurrence. We present a review of the literature reporting favorable results of radiofrequency ablation alone in locally recurrent small GCTB. New filling materials are also being developed to prevent non-oncological complications such as arthrosis and fractures. Routine measurement of tartrate-resistant acid phosphatase 5b in serum may be helpful in detecting early instances of local recurrence. For unresectable or metastatic GCTB, there is an urgent need for a new drug that is as effective as denosumab, avoids side effects, and can be administered to pregnant women.

Indexed as

CurettageDenosumabGiant cell tumor of boneRecurrenceRFATRACP 5b

Identifiers

PMID41568883
PMCPMC12825416

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.