Evidence map›Paper›PMID 41568724›Full record

ArticleThe Journal of international medical research2026

Does type 2 diabetes affect bone metabolism in patients after hip fracture? A case-control study.

Shaofeng Yang, Pengrui Jing, Bin Meng, Fanqi Kong

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Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Shaofeng YangDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, China.ORCID 0009-0007-1199-8813
Pengrui JingDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, China.
Bin MengDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, China.
Fanqi KongDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveThis study aimed to compare bone metabolism markers between patients with hip fracture who had and did not have type 2 diabetes mellitus (T2DM).MethodsA total of 743 patients with hip fractures were enrolled in this case-control study and were further divided into T2DM and non-T2DM groups. Biochemical parameters, including fasting blood glucose, triglycerides, and total cholesterol, and bone metabolism parameters, including total serum procollagen type N-terminal propeptide and age-related type I cross-linked C-telopeptide, were collected and compared. Correlations between fasting blood glucose and triglyceride levels and bone metabolism parameters were assessed via Spearman correlation analysis.ResultsThe fasting blood glucose and triglyceride levels in the T2DM group were significantly higher than those in the non-T2DM group. In addition, the total serum procollagen type N-terminal propeptide and age-related type I cross-linked C-telopeptide levels in the T2DM group were significantly lower than those in the non-T2DM group.ConclusionsThe fasting blood glucose levels were negatively correlated with the total serum procollagen type N-terminal propeptide and age-related type I cross-linked C-telopeptide levels. In addition, our study speculated that good glycemic control may be beneficial for bone metabolism.

Indexed as

Bone and BonesDiabetes Mellitus, Type 2Hip FracturesAgedAged, 80 and overBiomarkersBlood GlucoseCase-Control StudiesCollagen Type IFemaleHumansMaleMiddle AgedPeptide FragmentsPeptidesProcollagenBiomarkersBlood GlucoseCollagen Type Icollagen type I trimeric cross-linked peptidePeptide FragmentsPeptidesProcollagenprocollagen Type I N-terminal peptideTriglyceridesbone metabolism markersCROSSLHip fractureTP1NPtype 2 diabetes mellitus

Identifiers

PMID41568724
PMCPMC12833143

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