ArticleThe Journal of international medical research2026
Clinical and pathophysiological significance of circ-0049271 in acute ST-segment elevation myocardial infarction.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectiveST-segment elevation myocardial infarction is a life-threatening coronary artery disease associated with extensive myocardial injury. Circular RNAs are emerging regulators in cardiovascular disease. This study examined circ-0049271 expression in ST-segment elevation myocardial infarction, its clinical associations, and responsiveness to oxidative stress.MethodsFifty-five ST-segment elevation myocardial infarction patients and 35 healthy controls were enrolled. Blood was collected before percutaneous coronary intervention and at 0.5 and 48 h after the intervention. circ-0049271 expression was measured using quantitative reverse transcription polymerase chain reaction, and its correlations with the Gensini score, ischemic duration, cardiac biomarkers, and left ventricular ejection fraction were assessed. Human umbilical vein endothelial cells were exposed to hydrogen peroxide to assess circular RNA regulation under oxidative stress.Resultscirc-0049271 expression was elevated in ST-segment elevation myocardial infarction patients versus controls (
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