Observational studyAnnals of African medicine2026
Serum Resistin and High-sensitivity C-reactive Protein as Independent Predictors of Vascular Complications in Type 2 Diabetes Mellitus: A Cross-sectional Observational Study at a Tertiary Care Center.
Observational study in Annals of African medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSerum resistin has been implicated in atherosclerosis and vascular smooth muscle dysfunction through inflammatory pathways, making it a potential biomarker for cardiovascular risk. Comparative data in diabetic patients with acute vascular events are limited. This study evaluates serum resistin and high-sensitivity C-reactive protein (hs-CRP) levels in type 2 diabetes mellitus (T2DM) with acute myocardial infarction (AMI) or acute ischemic stroke (AIS) to explore their association with vascular complications. MATERIALS AND
methodsA cross-sectional, hospital-based study was conducted among T2DM patients presenting with AMI or AIS. Serum resistin, hs-CRP, glycated hemoglobin (HbA1c), lipid profile, and body mass index (BMI) were evaluated, and their associations with vascular events were statistically analyzed, considering P < 0.05 as statistically significant.
resultsThe mean serum resistin was significantly higher in the diabetes mellitus (DM) with AMI group (23.21 ± 5.65 ng/ml; P < 0.001) compared to controls (13.30 ± 2.94 ng/ml) but not in the DM with AIS group (19.90 ± 5.46 ng/ml; P = 0.215). hs-CRP was significantly elevated in both DM with AMI and AIS groups (3.43 ± 0.70 mg/l and 3.43 ± 1.01 mg/l, respectively) compared to controls (2.43 ± 0.62 mg/l; both P < 0.001). Positive correlations were observed between these biomarkers and conventional risk factors, including HbA1c, BMI, and low-density lipoprotein cholesterol.
conclusionElevated serum resistin (notably in AMI) and hs-CRP (in both AMI and AIS) in T2DM patients highlight a strong association between inflammation and acute vascular events. These biomarkers may serve as accessible tools for early risk stratification and targeted preventive strategies in high-risk diabetic populations.
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