ArticleOrganic & biomolecular chemistry2026
An integrative chemical and genomic similarity approach linking fungal secondary metabolites and biosynthetic gene clusters.
Article in Organic & biomolecular chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- From genome to field, biocontrol efficacy of Bacillus subtilis strain M10 against Rhizoctonia solani in common bean.Scientific reports · 2026Article
- Chemical Signaling and Metabolomic Crosstalk in Endophytic Fungi-Medicinal Plant Symbioses for Natural Product Discovery and Sustainable Bioproduction.Metabolites · 2026Review
- Machine-Readable Structural Information Is Essential for Natural Products Research.Journal of natural products · 2025Review
- Article
- Global patterns of diversity and distribution in Aspergillus fungi are driven by human and environmental influences.Current biology : CB · 2025Article
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11 authors.
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Abstract
Fungi are well known to biosynthesize structurally complex secondary metabolites (SMs) with diverse bioactivities. These fungal SMs are frequently produced by biosynthetic gene clusters (BGCs). Linking SMs to their BGCs is key to understanding their chemical and biological functions. Reasoning that structural similarity of SMs arises from similarities in the genes involved in their biosynthesis, we developed an integrative approach that leverages known SM-BGC pairs to infer links between detected SMs and genome-predicted BGC regions in fungi. As proof of concept, we structurally characterized 60 metabolites from metabolomic data of 16 strains of the filamentous fungus
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