Evidence map›Paper›PMID 41568568›Full record

ArticleJournal of the American Heart Association2026

Sex and Racial Differences in Left Atrial Appendage Morphology.

Ahmed Wahaj, Madeline E Mauri, Matthew J Bocchese, Alexander G G Quinn, Daohai Yu, Xiaoning Lu, Rebecca S Garber, George A Yesenosky, Anuj Basil, David M Fiss and 6 more

Erratum issuedAbstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Ahmed WahajRawalpindi Medical University Rawalpindi Pakistan.
Madeline E MauriDivision of Cardiology Lewis Katz School of Medicine at Temple University Philadelphia PA USA.
Matthew J BoccheseDivision of Cardiology Lewis Katz School of Medicine at Temple University Philadelphia PA USA.ORCID 0000-0003-0872-9560
Alexander G G QuinnDepartment of Internal Medicine Lewis Katz School of Medicine at Temple University Philadelphia PA USA.
Daohai YuDepartment of Biomedical Education and Data Science, Center for Biostatistics & Epidemiology Lewis Katz School of Medicine at Temple University Philadelphia PA USA.ORCID 0000-0003-1034-3130
Xiaoning LuDepartment of Biomedical Education and Data Science, Center for Biostatistics & Epidemiology Lewis Katz School of Medicine at Temple University Philadelphia PA USA.ORCID 0000-0002-9544-7395
Rebecca S GarberDepartment of Internal Medicine University of Illinois at Chicago Chicago IL USA.
George A YesenoskyDivision of Cardiology Lewis Katz School of Medicine at Temple University Philadelphia PA USA.
Anuj BasilDivision of Cardiology Lewis Katz School of Medicine at Temple University Philadelphia PA USA.
David M FissDivision of Cardiology Lewis Katz School of Medicine at Temple University Philadelphia PA USA.
Brian O'MurchuDivision of Cardiology Lewis Katz School of Medicine at Temple University Philadelphia PA USA.
Marissa J PietrolungoDivision of Cardiology Lewis Katz School of Medicine at Temple University Philadelphia PA USA.
Pravin V PatilDivision of Cardiology Lewis Katz School of Medicine at Temple University Philadelphia PA USA.
Gregory M MarcusDivision of Cardiology University of California San Francisco San Francisco CA USA.ORCID 0000-0001-5197-7696
Thomas A DewlandDivision of Cardiology University of California San Francisco San Francisco CA USA.ORCID 0000-0001-6069-7135
Isaac R WhitmanDivision of Cardiology Lewis Katz School of Medicine at Temple University Philadelphia PA USA.ORCID 0000-0002-2329-7690

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBlack and female patients with atrial fibrillation have more strokes. Certain left atrial appendage (LAA) morphologies impose a higher stroke risk. Whether anatomic differences in LAA morphology are associated with race or sex remains unexplored.

methodsWe identified consecutive patients with computed tomography for LAA morphology and categorized each patient by self-reported race (Black versus non-Black) and sex. Each LAA morphology was assigned a score based on published relative LAA thrombus risk (lowest to highest: "chicken wing," "windsock" and "cactus," "cauliflower"). Scores and prevalence were compared across races and sexes using a Wilcoxon rank-sum test and Fisher's exact test, respectively. Logistic regression was performed to find the association of race (adjusting for sex) and sex with higher risk LAA morphologies.

resultsAmong 211 patients (27% Black, n=58; 47% female, n=100), there was no difference in the projected hypothetical stroke risk across race or sex (median for Black versus non-Black patients: 1 [interquartile range, 1-4] versus 1 [interquartile range, 1-1],

conclusionsThe highest risk LAA morphology, cauliflower, demonstrated greater odds of being present in Black patients versus non-Black patients. The difference in women versus men did not reach statistical significance. Although the study was underpowered to make the findings declarative, these results are provocative regarding the differential stroke risk across races and sexes.

Indexed as

Atrial AppendageAtrial FibrillationBlack or African AmericanStrokeAgedFemaleHumansLogistic ModelsMaleMiddle AgedOdds RatioPrevalenceRetrospective StudiesRisk AssessmentRisk FactorsSex Factorsatrial fibrillationcerebrovascular accidentleft atrial appendagerace

Identifiers

PMID41568568
PMCPMC13055453

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.