Evidence map›Paper›PMID 41568559›Full record

ArticleJournal of the American Heart Association2026

Kristin Rädecke, David Rheinert, Annette Löwen, Felix Wiedmann, Sabrina Diebold, Federica Diofano, Birgit Weiß, Ralph Röth, Stefanie Schmitteckert, Sebastian Clauss and 5 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. NovelBiomedicines · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kristin RädeckeInstitute of Human Genetics University Hospital Heidelberg Germany.ORCID 0000-0003-1623-9182
David RheinertInstitute of Human Genetics University Hospital Heidelberg Germany.ORCID 0009-0004-0668-1342
Annette LöwenInstitute of Human Genetics University Hospital Heidelberg Germany.ORCID 0009-0003-4481-6239
Felix WiedmannDZHK (German Centre for Cardiovascular Research) Partner Site Heidelberg/Mannheim Heidelberg Germany.ORCID 0000-0001-8168-0025
Sabrina DieboldClinic for Internal Medicine II - Molecular Cardiology University Hospital Ulm Germany.
Federica DiofanoClinic for Internal Medicine II - Molecular Cardiology University Hospital Ulm Germany.
Birgit WeißInstitute of Human Genetics University Hospital Heidelberg Germany.ORCID 0000-0001-6800-4946
Ralph RöthInstitute of Human Genetics University Hospital Heidelberg Germany.ORCID 0000-0002-5032-3348
Stefanie SchmitteckertInstitute of Human Genetics University Hospital Heidelberg Germany.ORCID 0000-0001-9555-2614
Sebastian ClaussDepartment of Medicine I University Hospital, LMU Munich Germany.ORCID 0000-0002-5675-6128
Stefan KääbDepartment of Medicine I University Hospital, LMU Munich Germany.ORCID 0000-0001-8824-3581
Steffen JustClinic for Internal Medicine II - Molecular Cardiology University Hospital Ulm Germany.ORCID 0000-0001-7396-1281
Constanze SchmidtDZHK (German Centre for Cardiovascular Research) Partner Site Heidelberg/Mannheim Heidelberg Germany.ORCID 0000-0001-5897-237X
Gudrun A RappoldInstitute of Human Genetics University Hospital Heidelberg Germany.ORCID 0000-0002-3126-1508
Sandra HoffmannInstitute of Human Genetics University Hospital Heidelberg Germany.ORCID 0000-0001-8460-735X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia with a strong genetic predisposition. Genome-wide association studies have highlighted CAV1 (caveolin 1), a caveolar protein involved in various signaling pathways, as a candidate for cardiac conduction disorders.

methodsWe explored the role of CAV1 in AF in various models to dissect possible disease mechanisms. First,

resultsIn the porcine AF model,

conclusionsThis work underscores

Indexed as

Atrial FibrillationCaveolin 1AnimalsAnimals, Genetically ModifiedAtrioventricular NodeDisease Models, AnimalFemaleGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHeart AtriaHumansMaleSwineTranscription FactorsZebrafishCAV1 protein, humanCaveolin 1Transcription FactorsZebrafish Proteinsatrial fibrillationcaveolin 1noncoding variantsSHOX2

Identifiers

PMID41568559
PMCPMC13055488

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.