Evidence map›Paper›PMID 41568450›Full record

ArticleCancer medicine2026

Clinical Considerations of Splenic Dose Constraints to Mitigate Radiation-Induced Lymphopenia.

Yifu Ma, Shuying Zhang, Jiayan Ma, An Gao, Jiale Liu, He Ma, Qiyi Zhou, Jianjun Qian, Liyuan Zhang

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In one paragraph

Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yifu MaPRaG Therapy Center, Center for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0001-9676-5523
Shuying ZhangDepartment of Ultrasound, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jiayan MaDepartment of Experimental Center, The Second Affiliated Hospital of Soochow University, Suzhou, China.
An GaoPRaG Therapy Center, Center for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jiale LiuPRaG Therapy Center, Center for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou, China.
He MaPRaG Therapy Center, Center for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Qiyi ZhouPRaG Therapy Center, Center for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jianjun QianPRaG Therapy Center, Center for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Liyuan ZhangPRaG Therapy Center, Center for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0002-7469-1743

Funding

Internal Collaborative Research Program of the State Key Laboratory of Radiation Medicine and Radiation Protection (jointly established by the Ministry of Science and Technology and Jiangsu Province) GZN1202302National Natural Science Foundation of China 82573449Pioneer Talent Program of the Second Affiliated Hospital of Soochow University XKTJ-RC202401Suzhou Major Disease Multicenter Clinical Research Project DZXYJ202304
6 · The paper itself

Abstract

backgroundThe spleen dose-volume threshold for lymphopenia in abdominal radiotherapy has not yet reached a consensus. Our previous research indicated a correlation between these factors, but the threshold has not been determined. Therefore, we investigated the dynamic changes in lymphocytes during radiotherapy (RT), identified the spleen dose threshold, and examined how these factors affect patient prognosis.

methodsThe absolute lymphocyte counts (ALC) of gastric cancer patients were collected before, during, and after RT. Lymphocyte recovery status was assessed using the lymphocyte recovery index (LRI). LRI cut off was considered as insufficient recovery. Splenic dosimetric parameters were collected, and their impact on predicting grade 4 (G4) lymphopenia was evaluated using logistic regression analysis. Cox regression analysis was used to evaluate the relationship between lymphocyte depletion and recovery status and prognosis.

results159 patients were enrolled. The median ALC dropped by 85.71% after RT. The occurrence of G4 and G1-3 lymphopenia was observed in 30.2% and 69.8% of cases, respectively. There were 12.6% of patients whose ALC had recovered at 120 days after RT, while the remaining 87.4% were still accompanied by lymphopenia. Cox multivariable analysis showed that pTNM stage and LRI were independent prognostic factors affecting overall survival, and the independent prognostic factors for disease-free survival were pTNM stage and change in ALC. Splenic D

conclusionsPatients with severe lymphocyte decline during RT and insufficient lymphocyte recovery afterward have a worse prognosis. It is important not only to prevent severe lymphopenia during RT but also to focus on improving lymphocyte recovery after RT. Constraining the spleen V

Indexed as

LymphopeniaRadiation InjuriesSpleenStomach NeoplasmsAdultAgedAged, 80 and overFemaleHumansLymphocyte CountMaleMiddle AgedPrognosisRadiotherapy Dosagelymphocyte recovery indexlymphopeniaradiotherapyspleen

Identifiers

PMID41568450
PMCPMC12824635

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.